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UPC CFI 140/2024

Mar 26, 2024·EP2697391 +1 more: METHOD AND PRODUCT FOR LOCALISED OR SPATIAL DETECTION OF NUCLEIC ACID IN A TISSUE SAMPLE

Case details
Status
Case Closed
Action
Infringement
Category
Main Infringement Action
Parties
Claimants
Reps: Tilman Müller-Stoy (Bardehle Pagenberg); Martin Drews (Bardehle Pagenberg); Axel Berger (Bardehle Pagenberg)
Respondents
Reps: Agathe Michel-De Cazotte (Carpmaels & Ransford); Cameron Marshall (Carpmaels & Ransford); Christoph Höhne; Isabelle Schaller
Division
Dusseldorf LD
Judges
Technology
Biotech · Genomics · Biotechnology
Language
English
First decided
Apr 27, 2026
Claims
At issueall
Infringedall
Notes: Düsseldorf LD found Curio Bioscience infringes EP2697391 (spatial nucleic acid detection); operative part grants injunction without specifying individual claim numbers, action partly dismissed.
Decisions
  • 2026-04-27
    Infringement Action

    The Court ordered the release of the security for costs of €200,000 deposited by the Defendant pursuant to the Court's order of 3 December 2024. Following the resolution of cost proceedings (UPC_CFI_657/2025 and UPC_CFI_658/2025) and payment of the awarded amounts, the Claimant did not object to release. The security was released under R. 352.2 RoP by analogy.

    Legal issues:Release of security for costs under R. 352.2 RoP by analogyCessation of claimant's interest in retaining security following satisfaction of cost orders
  • 2025-06-16
    InfringedInjunction grantedInfringement meritsInfringement Action

    Decision of the Düsseldorf Local Division finding that Curio Bioscience infringes EP 2 697 391 B1 owned by 10x Genomics. The court ordered: (A) cessation of the infringing acts in UPC member states; (B) recall from distribution channels; (C) permanent removal from distribution channels; (D) rendering of accounts; (E) damages for acts after 30 November 2019; (F) periodic penalty payments of up to EUR 100,000 per day. The action was dismissed in other respects. Costs: borne 30% by claimant, 70% by defendant. Value in dispute set at EUR 3,000,000; ceiling for recoverable representation costs EUR 400,000.

    Legal issues:Claim construction – independent construction by the courtFirst reference to subclaims at oral hearing – admissibilityInfringement under Art. 25 UPCAInjunction, recall, removal and destruction under Art. 63-64 UPCA
    Damages: Liability declared, amount deferred
  • 2024-08-08
    Application RoP262A

    Procedural order on a confidentiality club application (Rule 262A RoP) in proceedings involving 10x Genomics v Curio Bioscience. The court set rules for access to confidential information, including access for named party representatives and their teams, with responsibility for maintaining confidentiality.

    Legal issues:Confidentiality order (Rule 262A RoP)Access to confidential informationIdentification of persons in confidentiality clubResponsibility for breach of confidentiality
Documents
Document titleDatePublic
action.issueOrder.order2026-04-27Not public
Order2026-04-27Public
Receipt2026-04-16Not public
Cover sheet2026-04-16Not public
Document Claimant2026-04-16Not public
action.communication.general2026-04-07Not public
Receipt2026-04-02Not public
Cover sheet2026-04-02Not public
Exhibit Claimant2026-04-02Not public
Application document Claimant2026-04-02Not public
Application document Claimant2026-04-02Not public
Application document Claimant2026-04-02Not public
Receipt2026-01-26Not public
Cover sheet2026-01-26Not public
Other document Defendant2026-01-26Not public
Case Closure Formal Check2025-09-15Not public
Receipt2025-07-01Not public
Exhibit B21b - 10xGenomics2025-07-01Not public
Exhibit B21c - 10xGenomics2025-07-01Not public
Exhibit B21a - 10xGenomics2025-07-01Not public
Enforcement - Brief of 10xGenomics2025-07-01Not public
Headnote-and-Keywords2025-06-16Not public
DecisionOutcome2025-06-16Not public
Decision2025-06-16Public
Decision2025-06-16Not public
Order to provide the decision2025-06-16Not public
Response to Curios brief re. confidentiality club2025-06-11Not public
Opportunity to respond2025-06-04Not public
2025.06.03 - Response to 10x brief dated 24 May 2025_signed2025-06-03Not public
Exhibit A2025-06-03Not public
Exhibit B2025-06-03Not public
Opportunity to respond2025-05-27Not public
Response of 10x Genomics2025-05-27Not public
Opportunity to comment2025-05-20Not public
Opportunity to comment2025-05-20Not public
2025.05.19 - Response to 10x R. 262A application2025-05-19Not public
15774-2024_OH_DUS-LOC_UPC202505130930AM_S012025-05-14Not public
15774-2024_OH_DUS-LOC_UPC202505130930AM_S012025-05-14Not public
Receipt2025-05-12Not public
R. 262A RoP - Pre Order2025-05-12Not public
Interim-Procedure-Closure2025-05-10Not public
Summon-Oral-Hearing2025-05-10Not public
Summon to the oral hearing2025-05-10Public
Hearing-Dates2025-05-10Not public
2025.05.09 - Response to comply with the Order2025-05-09Not public
Confidentiality request - 10x Genomics RoP262A2025-05-09Not public
Confidentiality request - 10x Genomics RoP262.22025-05-09Not public
Exhibit BP192025-05-09Not public
Response of 10x Genomics2025-05-09Not public
Exhibit BP202025-05-09Not public
Outcome of the Order2025-05-06Not public
Closing of the workflow2025-05-06Public
Receipt_physicalExhibit2025-05-06Not public
Annex 22025-05-06Not public
Receipt_physicalExhibit2025-05-06Not public
Annex 12025-05-06Not public
Receipt2025-05-06Not public
Annex 22025-05-05Not public
25050505_15774_2024_21268_2025_EIP2025-05-05Not public
Annex 12025-05-05Not public
Hearing-Dates2025-05-02Not public
Summon to the oral hearing2025-05-02Public
Headnote-and-Keywords2025-05-02Not public
R. 103 RoP Order2025-05-02Public
Written-Procedure-Closure2025-05-02Not public
Headnote-and-Keywords2025-04-30Not public
Outcome of the Order2025-04-30Not public
R. 9 RoP Order2025-04-30Public
Receipt2025-04-30Not public
2025.04.29 - Rule 9 Application (access to Curio Seeker Kit)2025-04-29Not public
Closure of the written procedure2025-02-26Public
Template-Order2025-02-26Not public
Outcome of the Order2025-01-28Not public
R. 353 RoP Order2025-01-28Public
Panel-Appointment2025-01-24Not public
Outcome of the Order2025-01-21Not public
R. 33 RoP Order2025-01-21Public
Template-Order2025-01-21Not public
Submission2025-01-21Not public
Opportunity to comment2025-01-18Not public
Receipt2025-01-15Not public
2025.01.14 Application for allocation of a TQJ2025-01-14Not public
Hearing-Dates2025-01-09Not public
R. 28 RoP Order2025-01-09Public
Template-Order2025-01-09Not public
Template-Order2025-01-09Not public
Exhibit_BP18_10x_Genomics2025-01-08Not public
Response re oral hearing date - 10x Genomics2025-01-08Not public
Opportunity to comment2025-01-07Not public
Opportunity to comment2025-01-07Not public
Opportunity to comment2025-01-03Not public
Receipt2025-01-03Not public
Application pursuant to RoP 353 - 10xGenomics2025-01-03Not public
Receipt2025-01-02Not public
Evidence of Compliance with Court Order on Security for Costs2024-12-31Not public
Transfer Confirmation2024-12-31Not public
R. 28 RoP - Pre Order2024-12-18Not public
Hearing-Dates2024-12-18Not public
Headnote-and-Keywords2024-12-03Not public
Outcome of the Order2024-12-03Not public
R. 158 RoP Order2024-12-03Public
R. 158 RoP Order2024-12-03Not public
Acknowledgement-of-lodging2024-10-16Not public
Exhibit_EIP_22024-10-16Not public
20241016_15774.2024_UPC_EIP_Rejoinder2024-10-16Not public
Exhibit_EIP_12024-10-16Not public
Exhibit_EIP_62024-10-16Not public
Exhibit_EIP_52024-10-16Not public
Exhibit_EIP_42024-10-16Not public
Exhibit_EIP_32024-10-16Not public
Submission2024-09-24Not public
Acknowledgement-of-lodging2024-09-17Not public
Submission2024-09-17Not public
BP172024-09-17Not public
Opportunity to comment2024-09-10Not public
2024.09.10 - Response to security for costs application2024-09-10Not public
Opportunity to respond2024-08-27Not public
Receipt2024-08-27Not public
Receipt2024-08-27Not public
R262 Confidentiality request2024-08-26Not public
Request for security for costs2024-08-26Not public
Request for security for costs2024-08-26Not public
Acknowledgement-of-lodging2024-08-09Not public
Formal-checks_Notification-of-positive-outcome2024-08-09Not public
Exhibit CR-82024-08-09Not public
Exhibit CR-42024-08-09Not public
2024.07.15 - Curio - Grounds for amended valuation2024-08-09Not public
CONFIDENTIAL Exhibit CR-12024-08-09Not public
Exhibit CR-72024-08-09Not public
Exhibit CR-52024-08-09Not public
CONFIDENTIAL Exhibit CR-22024-08-09Not public
2024.07.15 - Curio - CONFIDENTIAL Statement of Defence2024-08-09Not public
Exhibit CR-92024-08-09Not public
2024.07.17 - Application to change the details of a representative in a pending case2024-08-09Not public
2024.07.17 - Updated Statement of Defence2024-08-09Not public
Exhibit CR-32024-08-09Not public
Exhibit CR-62024-08-09Not public
Acknowledgement-of-lodging2024-08-09Not public
Application2024-08-09Not public
Outcome of the Order2024-08-08Not public
Closing of the workflow for technical reasons2024-08-08Public
Formal-checks_Request-for-correction2024-08-08Not public
Headnote-and-Keywords2024-08-08Not public
R. 262A RoP Order2024-08-08Public
R. 262A RoP Order2024-08-08Not public
CONFIDENTIAL Exhibit CR-22024-08-06Not public
Exhibit CR-32024-08-06Not public
2024.07.15 - Curio - CONFIDENTIAL Statement of Defence2024-08-06Not public
Exhibit CR-42024-08-06Not public
Exhibit CR-52024-08-06Not public
2024.07.15 - Curio - Grounds for amended valuation2024-08-06Not public
Exhibit CR-92024-08-06Not public
Exhibit CR-62024-08-06Not public
CONFIDENTIAL Exhibit CR-12024-08-06Not public
Exhibit CR-82024-08-06Not public
Exhibit CR-72024-08-06Not public
2024.07.17 - Application to change the details of a representative in a pending case2024-08-06Not public
2024.07.17 - Updated Statement of Defence2024-08-06Not public
Opportunity to comment2024-08-01Not public
Submission2024-07-31Not public
Formal-checks_Request-for-correction2024-07-22Not public
Opportunity to comment R. 262A RoP2024-07-17Not public
Opportunity to comment R. 262A RoP2024-07-17Not public
Acknowledgement-of-lodging2024-07-17Not public
2024.07.17 - Application to change the details of a representative in a pending case2024-07-17Not public
Exhibit CR-32024-07-17Not public
2024.07.17 - Updated Statement of Defence2024-07-17Not public
Exhibit CR-62024-07-17Not public
2024.07.15 - Curio - Grounds for amended valuation2024-07-17Not public
CONFIDENTIAL Exhibit CR-22024-07-17Not public
Exhibit CR-82024-07-17Not public
CONFIDENTIAL Exhibit CR-12024-07-17Not public
Exhibit CR-72024-07-17Not public
Exhibit CR-92024-07-17Not public
Exhibit CR-42024-07-17Not public
2024.07.17 - Application to change the details of a representative in a pending case2024-07-17Not public
2024.07.15 - Curio - CONFIDENTIAL Statement of Defence2024-07-17Not public
Exhibit CR-52024-07-17Not public
Formal-checks_Request-for-correction2024-07-17Not public
2024.07.15 - Curio - Confidentiality request2024-07-15Not public
Acknowledgement-of-lodging2024-07-15Not public
Exhibit CR-72024-07-15Not public
Exhibit CR-42024-07-15Not public
2024.07.15 - Curio - CONFIDENTIAL Statement of Defence2024-07-15Not public
Exhibit CR-52024-07-15Not public
CONFIDENTIAL Exhibit CR-12024-07-15Not public
CONFIDENTIAL Exhibit CR-22024-07-15Not public
CONFIDENTIAL Exhibit CR-12024-07-15Not public
CONFIDENTIAL Exhibit CR-22024-07-15Not public
2024.07.15 - Curio - CONFIDENTIAL Statement of Defence2024-07-15Not public
2024.07.15 - Curio - Grounds for amended valuation2024-07-15Not public
Exhibit CR-32024-07-15Not public
Exhibit CR-92024-07-15Not public
Exhibit CR-82024-07-15Not public
Exhibit CR-62024-07-15Not public
Panel-Appointment2024-04-30Not public
Headnote-and-Keywords2024-04-29Not public
Outcome of the Order2024-04-29Not public
Wechsel der Verfahrenssprache2024-04-29Public
Outcome of the Order2024-04-29Not public
Wechsel der Verfahrenssprache2024-04-29Public
Receipt2024-04-24Not public
Antrag/Schriftsatz2024-04-24Not public
Receipt2024-04-24Not public
Language change request2024-04-23Not public
Confirmation of notification of appointment2024-04-22Not public
Zustellung Curio Bioscience Inc.2024-04-22Not public
Acknowledgement of access to case2024-04-21Not public
epoUploadDocumentsWorkflow2024-04-02Not public
Document from EPO2024-03-29Not public
Letter for Service2024-03-27Not public
Panel-Appointment2024-03-27Not public
EPO-Request-for-case-pending2024-03-27Not public
Receipt2024-03-27Not public
Formal-checks_Notification-of-positive-outcome2024-03-27Not public
Panel-Appointment2024-03-26Not public
Acknowledgement-of-lodging2024-03-25Not public
Anlage BP102024-03-25Not public
Anlage BP042024-03-25Not public
Anlage BP092024-03-25Not public
Klage2024-03-25Not public
Anlage BP152024-03-25Not public
Anlage BP14a Teil 32024-03-25Not public
Anlage BP14a Teil 12024-03-25Not public
Anlage BP132024-03-25Not public
Anlage BP122024-03-25Not public
Anlage BP002024-03-25Not public
Anlage BP112024-03-25Not public
Anlage BP 14a Teil 22024-03-25Not public
Anlage BP162024-03-25Not public
Anlage Proof of payment court fees2024-03-25Not public
Anlage BP14 Teil 12024-03-25Not public
Anlage BP05a2024-03-25Not public
Anlage BP082024-03-25Not public
Anlage BP16a2024-03-25Not public
Anlage BP14 Teil 32024-03-25Not public
Anlage BP052024-03-25Not public
Anlage BP14 Teil 2.22024-03-25Not public
Anlage BP032024-03-25Not public
Anlage BP14 Teil 2.12024-03-25Not public
Anlage BP072024-03-25Not public
Anlage BP022024-03-25Not public
Anlage BP062024-03-25Not public
Anlage BP012024-03-25Not public
Coverage: Partial.Reasoning extracted with partial coverage — some sections may be incomplete.
Plain-English summary

10x Genomics, Inc. sued Curio Bioscience Inc. for infringement of EP 2 697 391 B1, a patent for localised/spatial detection of nucleic acid in tissue samples (spatial transcriptomics), at the Düsseldorf Local Division. The court found infringement and ordered Curio to cease infringing acts, recall products from commerce, permanently remove them from distribution, provide a full accounting, and pay damages for acts from 30 November 2019 onwards, with penalty payments of up to EUR 100,000 per day for non-compliance.

Accepted arguments
What the court agreed with — by party.

  • Infringement of EP 2 697 391 B1 by Curio Bioscience's spatial transcriptomics products

    ClaimantLegal basis: Art. 25 UPCA

    Note: The Düsseldorf Local Division found Curio Bioscience liable for infringing 10x Genomics' spatial transcriptomics patent and granted an injunction, recall, removal from commerce, and accounting.

  • First reference to additional subclaims at oral hearing admissible where feature was already in dispute and subclaims merely provide additional arguments

    Claimant

    Note: Court articulated this as a headnote, citing the Court of Appeal's Insulet v. EOFlow ruling that claim construction is a matter of law and the court construes claims independently.

Rejected arguments
What the court did not agree with — and why.

  • Remaining requests in the infringement action

    Claimant

    Reason: Action dismissed in other respects (no detail in excerpt).

Key legal principles
Doctrines and rules cited in the reasoning.
Claim construction is a matter of law; court must independently construe claims (citing UPC_CoA_768/2024 Insulet v EOFlow)First reference to subclaims at oral hearing admissible if the feature was already in dispute and subclaims add arguments onlyConfidentiality orders under R. 262A RoP in summary proceedings do not preclude a separate order in main proceedingsNumber of persons with access to confidential information should not be unlimited but must enable effective representation

Browse other cases on this principle.

Claim construction notes

The court confirmed that claim construction is a matter of law and must be performed independently by the court. On subclaim admissibility, the court held that first reference to subclaims at oral hearing is admissible where the disputed feature was already in issue and the subclaims provide additional legal arguments rather than new factual assertions.