UPC CFI 463/2023
Dec 4, 2023·EP2697391 +1 more: METHOD AND PRODUCT FOR LOCALISED OR SPATIAL DETECTION OF NUCLEIC ACID IN A TISSUE SAMPLE
- Case details
- StatusCase ClosedActionProvisional measuresCategoryProvisional Measures
- Parties
- ClaimantsReps: Tilman Müller-Stoy (Bardehle Pagenberg); Martin Drews (Bardehle Pagenberg); Axel Berger (Bardehle Pagenberg)
- Division
- Dusseldorf LD
- Technology
- Biotechnology
- Language
- English
- First decided
- Jan 29, 2024
- Last decision
- Feb 14, 2024
- 2024-04-30PI grantedPreliminary injunctionApplication for provisional measures
The Düsseldorf Local Division granted a preliminary injunction against Curio Bioscience Inc. prohibiting it from offering, marketing, using, importing or storing arrays for spatially localised nucleic acid detection in Germany, France and Sweden, finding prima facie infringement of EP 2 697 391 B1 (owned by 10x Genomics). Both parties were ordered to pay each other interim costs of EUR 100,000. The injunction was conditional on 10x Genomics providing security of EUR 2,000,000. 10x Genomics' application for security for costs from the defendant was rejected.
Legal issues:Standing and patent register presumption under Rule 8.5(c) RoPPurpose-limiting claim features and scope of protectionUrgency and knowledge of infringement in provisional measuresSecurity for costs in provisional measures proceedingsApplicability of Rule 158 RoP to defendantsDamages: 100,000 - 2024-02-14Application for provisional measures
The Düsseldorf Local Division issued a procedural order in 10x Genomics v. Curio Bioscience establishing a structured confidentiality protection procedure under Rule 262A RoP, clarifying the CMS workflow for trade secret protection and setting out the process for granting preliminary access restrictions before a final confidentiality order is made.
Legal issues:Rule 262A RoP: confidentiality protection workflow in CMSPreliminary access restrictions pending final confidentiality orderHearing requirement before final confidentiality order (Rule 262A.4 RoP)Trade secret protection in interim proceedings - 2024-01-29Application for provisional measures
The Düsseldorf Local Division issued a procedural order in the 10x Genomics v. Curio Bioscience provisional measures proceedings, deciding ex officio to appoint a technically qualified judge given the technical complexity of the patent (spatial transcriptomics), relying on Art. 8(5) UPCA even in the absence of an express provision for interim proceedings.
Legal issues:Art. 8(5) UPCA and Rule 34 RoP: appointment of technically qualified judge ex officio in provisional measures proceedingsPatent validity as condition for provisional measures
| Document title | Date | Public |
|---|---|---|
| Headnote-and-Keywords | 2025-06-04 | Not public |
| Outcome of the Order | 2025-06-04 | Not public |
| Amendment of the confidentiality club | 2025-06-04 | Not public |
| Amendment of the confidentiality club | 2025-06-04 | Public |
| 04.06.2025 - Response to 10x request regarding 11 March 2024 confidentiality club_signed | 2025-06-04 | Not public |
| Opportunity to comment | 2025-05-28 | Not public |
| Opportunity to respond | 2025-05-28 | Not public |
| Receipt | 2025-05-28 | Not public |
| Request for extension of confidentiality club | 2025-05-28 | Not public |
| Headnote-and-Keywords | 2025-02-20 | Not public |
| Outcome of the Order | 2025-02-20 | Not public |
| R. 352 RoP Order | 2025-02-20 | Public |
| Opportunity to comment | 2025-01-18 | Not public |
| Receipt | 2025-01-16 | Not public |
| Release of deposit - Application of 10x Genomics | 2025-01-15 | Not public |
| Exhibit BP 41 - 10x Genomics | 2025-01-15 | Not public |
| Exhibit BP 43 - 10x Genomics | 2025-01-15 | Not public |
| Exhibit BP42 - 10x Genomics | 2025-01-15 | Not public |
| Outcome of the Order | 2024-05-14 | Not public |
| Order re enforcement security | 2024-05-14 | Public |
| Template-Order | 2024-05-14 | Not public |
| Receipt | 2024-05-14 | Not public |
| Schriftsatz | 2024-05-14 | Not public |
| BP40 | 2024-05-14 | Not public |
| Panel-Appointment | 2024-04-30 | Not public |
| Headnote-and-Keywords | 2024-04-30 | Not public |
| Headnote-and-Keywords | 2024-04-30 | Not public |
| Certified translation of the R. 211.1 RoP Order | 2024-04-30 | Not public |
| Certified translation of the R. 211.1 RoP Order | 2024-04-30 | Public |
| Measures_DecisionOutcome_Notification.pdf | 2024-04-30 | Not public |
| Order R. 211.1 RoP | 2024-04-30 | Public |
| Order R. 211.1 RoP | 2024-04-30 | Not public |
| Headnote-and-Keywords | 2024-04-23 | Not public |
| Order re R. 14.2 (c) RoP | 2024-04-23 | Public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S03/C | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S03/C | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S01/C | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S03 | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S02 | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S01 | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S03 | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S04/C | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S02/C | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S04/C | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S02 | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S02/C | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S01 | 2024-04-16 | Not public |
| 590953/2023/OH/DUS-LOC/UPC202403260930AM/S01/C | 2024-04-16 | Not public |
| Receipt | 2024-03-27 | Not public |
| Application | 2024-03-27 | Not public |
| Exhibit CR-26 CONFIDENTIAL | 2024-03-27 | Not public |
| Application | 2024-03-27 | Not public |
| Hinweise Simultanverdolmetschung im Sitzungssaal | 2024-03-22 | Public |
| Outcome of the Order | 2024-03-22 | Not public |
| Anordnung R. 109 VerfO | 2024-03-22 | Public |
| Schließung Workflow | 2024-03-22 | Public |
| Outcome of the Order | 2024-03-22 | Not public |
| Schließung Workflow | 2024-03-22 | Public |
| Verfahrensanordnung R. 262A VerfO | 2024-03-22 | Public |
| Curio Comments | 2024-03-21 | Not public |
| Hinweis Kostenerstattung im Eilverfahren | 2024-03-21 | Public |
| Template-Order | 2024-03-21 | Not public |
| Hinweis Kosten im Eilverfahren | 2024-03-21 | Not public |
| Schriftsatz | 2024-03-20 | Not public |
| Gelegenheit zur Stellungnahme | 2024-03-20 | Not public |
| Receipt | 2024-03-20 | Not public |
| Antrag/Schriftsatz | 2024-03-20 | Not public |
| Opportunity to Comment R. 262A.4 RoP | 2024-03-18 | Not public |
| 2024.03.15 Confidentiality (R. 262A VerfO) | 2024-03-15 | Not public |
| Exhibit CR-21 | 2024-03-15 | Not public |
| Exhibit CR-24 | 2024-03-15 | Not public |
| 2024.03.15 - Response to 10x reply to objection | 2024-03-15 | Not public |
| 2024.03.15 - Response to 10x reply to objection | 2024-03-15 | Not public |
| Exhibit CR-23 | 2024-03-15 | Not public |
| Exhibit CR-22 | 2024-03-15 | Not public |
| Exhibit CR-18 | 2024-03-15 | Not public |
| Exhibit CR-25 | 2024-03-15 | Not public |
| Exhibit CR-20 | 2024-03-15 | Not public |
| Exhibit CR-19 | 2024-03-15 | Not public |
| Final Order R. 262A | 2024-03-11 | Public |
| 2024.03.08 - Response to 10x submission regarding protection of confidential information | 2024-03-08 | Not public |
| Gelegenheit zur Stellungnahme | 2024-03-04 | Not public |
| Receipt | 2024-03-02 | Not public |
| Gelegenheit zur Stellungnahme | 2024-03-01 | Not public |
| Application R 262.2 VerfO | 2024-03-01 | Not public |
| Anlage BP27 | 2024-03-01 | Not public |
| Anlage BP26 | 2024-03-01 | Not public |
| Anlage BP36 | 2024-03-01 | Not public |
| Anlage BP28 | 2024-03-01 | Not public |
| Anlage BP31 | 2024-03-01 | Not public |
| Anlage BP30 | 2024-03-01 | Not public |
| Anlage BP22 | 2024-03-01 | Not public |
| Anlage BP33 | 2024-03-01 | Not public |
| Anlage BP38 | 2024-03-01 | Not public |
| Anlage BP23 | 2024-03-01 | Not public |
| Anlage BP21 | 2024-03-01 | Not public |
| Anlage BP20 | 2024-03-01 | Not public |
| Anlage BP35 | 2024-03-01 | Not public |
| Anlage BP19 | 2024-03-01 | Not public |
| Erwiderung Teil 1 (Nicht vertraulich) | 2024-03-01 | Not public |
| Anlage BP08a | 2024-03-01 | Not public |
| Anlage BP32 | 2024-03-01 | Not public |
| Anlage BP37 | 2024-03-01 | Not public |
| Erwiderung Teil 2 (Vertraulich) | 2024-03-01 | Not public |
| Erwiderung Teil 2 (Vertraulich) | 2024-03-01 | Not public |
| Anlage BP29 | 2024-03-01 | Not public |
| Anlage BP09a | 2024-03-01 | Not public |
| Anlage BP07a | 2024-03-01 | Not public |
| Anlage BP25 | 2024-03-01 | Not public |
| Anlage BP24 | 2024-03-01 | Not public |
| Anlage BP34 | 2024-03-01 | Not public |
| Anlage BP18 | 2024-03-01 | Not public |
| Anlage BP03a | 2024-03-01 | Not public |
| Comments to Application RoP 262A | 2024-03-01 | Not public |
| Outcome of the Order | 2024-03-01 | Not public |
| Verfahrensanordnung R. 109 VerfO | 2024-03-01 | Public |
| Gelegenheit zur Stellungnahme zum Antrag nach R. 109 VerfO | 2024-02-26 | Not public |
| Outcome of the Order | 2024-02-26 | Not public |
| Entscheidung R. 323.1 VerfO | 2024-02-26 | Public |
| Receipt | 2024-02-26 | Not public |
| Schriftsatz | 2024-02-26 | Not public |
| Outcome of the Order | 2024-02-23 | Not public |
| Zurückweisung Fristverlängerungsantrag | 2024-02-23 | Public |
| Receipt | 2024-02-23 | Not public |
| Schriftsatz | 2024-02-23 | Not public |
| Vorläufige Geheimnisschutzanordnung und Gelegenheit zur Stellungnahme | 2024-02-23 | Not public |
| Response to order dated 20 February R. 262A VerfO (signed) | 2024-02-22 | Not public |
| Gelegenheit zur Stellungnahme R. 262A, R. 264 VerfO | 2024-02-20 | Not public |
| Schriftsatz | 2024-02-20 | Not public |
| 2024.02.20 - Comments to Procedural Order App_85002024 dated 16 February (signed) | 2024-02-20 | Not public |
| Exhibit App CR-1 | 2024-02-20 | Not public |
| Korrektur der E-Mailadresse der Kanzlei in der Ladungsanordnung | 2024-02-19 | Public |
| Gelegenheit zur Erwiderung auf den Einspruchsschriftsatz | 2024-02-16 | Not public |
| summons | 2024-02-16 | Not public |
| Ladung zur mündlichen Verhandlung | 2024-02-16 | Public |
| Template-Order | 2024-02-16 | Not public |
| Ladung zur mündlichen Verhandlung | 2024-02-16 | Not public |
| Verfahrensleitende Anordnung | 2024-02-16 | Public |
| Gelegenheit zur Stellungnahme R. 262A VerfO | 2024-02-16 | Not public |
| Art 58 UPCA Application | 2024-02-16 | Not public |
| Aufforderung zur Verwendung R. 262A-Workflow | 2024-02-15 | Public |
| CR-12 | 2024-02-15 | Not public |
| CR-1 | 2024-02-15 | Not public |
| CR-8 | 2024-02-15 | Not public |
| CONFIDENTIAL CR-3 | 2024-02-15 | Not public |
| CR-11b | 2024-02-15 | Not public |
| CR-14 | 2024-02-15 | Not public |
| CR-7 | 2024-02-15 | Not public |
| CR-13c | 2024-02-15 | Not public |
| CR-5 | 2024-02-15 | Not public |
| CR-6 | 2024-02-15 | Not public |
| CR-13b | 2024-02-15 | Not public |
| 2024.02.15 - CR-DE Confidential Objection to Application for provisional measures | 2024-02-15 | Not public |
| CR-11a | 2024-02-15 | Not public |
| CR-10 | 2024-02-15 | Not public |
| 2024.02.15 - CR-DE Confidential Objection to Application for provisional measures | 2024-02-15 | Not public |
| CR-17 | 2024-02-15 | Not public |
| CONFIDENTIAL CR-3 | 2024-02-15 | Not public |
| CR-15 | 2024-02-15 | Not public |
| 2024.02.15 - CR-DE Confidential Objection to Application for provisional measures | 2024-02-15 | Not public |
| CR-2 | 2024-02-15 | Not public |
| CR-9 | 2024-02-15 | Not public |
| Art 58 UPCA application | 2024-02-15 | Not public |
| CR-16 | 2024-02-15 | Not public |
| CR-13a | 2024-02-15 | Not public |
| CR-4 | 2024-02-15 | Not public |
| Outcome of the Order | 2024-02-14 | Not public |
| Schließung Workflow | 2024-02-14 | Public |
| Outcome of the Order | 2024-02-14 | Not public |
| Hinweise zum Verfahren R. 262A VerfO | 2024-02-14 | Public |
| Receipt | 2024-02-14 | Not public |
| Application pursuant to RoP 9 | 2024-02-14 | Not public |
| Receipt | 2024-02-14 | Not public |
| Confidentiality request | 2024-02-13 | Not public |
| Schriftsatz | 2024-02-12 | Not public |
| Entscheidung über die Fristverlängerungsbitte der Antragstellerin | 2024-02-05 | Public |
| Anhörung R. 323.2 VerfO | 2024-02-01 | Not public |
| Outcome of the Order | 2024-02-01 | Not public |
| Möglichkeit der Stellungnahme | 2024-02-01 | Public |
| Receipt | 2024-02-01 | Not public |
| Schriftsatz | 2024-02-01 | Not public |
| Verfahrensleitende Anordnung | 2024-02-01 | Not public |
| Receipt | 2024-01-30 | Not public |
| Language request | 2024-01-30 | Not public |
| Hinzuziehung eines TQJ | 2024-01-29 | Not public |
| Comments on ORD_3015/2024 | 2024-01-29 | Not public |
| Möglichkeit zum Upload der Stellungnahme der Antragsgegnerin | 2024-01-25 | Not public |
| Comments on ORD_3015/2024 | 2024-01-25 | Not public |
| Notification Of Service | 2024-01-22 | Not public |
| Zustellung Curio Bioscience | 2024-01-22 | Not public |
| Acknowledgement of access to case | 2024-01-22 | Not public |
| Hinzuziehung eines TQJ | 2024-01-18 | Not public |
| Aufforderung zur Erhebung Einspruch | 2023-12-05 | Not public |
| Aufforderung zur Erhebung Einspruch | 2023-12-05 | Not public |
| Template-Order | 2023-12-05 | Not public |
| Aufforderung zur Erhebung Einspruch | 2023-12-05 | Not public |
| Aufforderung zur Erhebung Einspruch | 2023-12-05 | Not public |
| Letter for Service | 2023-12-05 | Not public |
| Panel-Appointment | 2023-12-05 | Not public |
| Application-For-Measures-Receipt | 2023-12-05 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2023-12-05 | Not public |
| Application-For-Measures-Acknowledgement | 2023-12-04 | Not public |
| Anlage BP03 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP15 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP17a - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP17 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP14 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP12 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP06 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP13 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP05 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP01 - 10x Genomics | 2023-12-04 | Not public |
| Antrag auf Erlass einstweiliger Maßnahmen | 2023-12-04 | Not public |
| Anlage BP15a - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP02 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP04 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP11 - 10x Genomcis | 2023-12-04 | Not public |
| Anlage BP09 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP08 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP10 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP07 - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP12a - 10x Genomics | 2023-12-04 | Not public |
| Anlage BP16 - 10x Genomics | 2023-12-04 | Not public |
10x Genomics obtained a preliminary injunction before the Düsseldorf Local Division against Curio Bioscience prohibiting it from offering, marketing, using, importing or storing spatially-localised nucleic acid detection arrays in Germany, France and Sweden, finding prima facie infringement of EP 2 697 391 B1. The PI was conditional on 10x Genomics providing EUR 2,000,000 security; each party was ordered to pay the other EUR 100,000 in interim costs; Curio's application for security for costs was rejected as inapplicable in ex parte urgent proceedings.
10x Genomics has prima facie standing as registered proprietor of EP 2 697 391 B1
ClaimantLegal basis: R. 8.5(c) RoPNote: Headnote 1: registration in the national patent register gives rise to a rebuttable presumption of entitlement; burden shifts to respondent to disprove.
prima facie infringement of EP 2 697 391 B1 (spatial transcriptomics array) by Curio Bioscience
ClaimantLegal basis: Art. 62 UPCA; R. 211 RoPNote: Court found sufficient prima facie case to grant PI; purpose-bound claim elements (Zweckangaben) were interpreted as limiting scope to arrays suitable for the stated purpose.
purpose statements in patent claims limit the protected subject matter to items suitable for the stated purpose
ClaimantLegal basis: Art. 69 EPCNote: Headnote 2: purpose indications in claims define the subject matter to require suitability for that purpose, not merely geometric features.
urgency established: knowledge of infringement arises from constructive knowledge where patent holder is put on notice of circumstances likely indicating infringement
ClaimantLegal basis: Art. 62 UPCA; R. 211 RoPNote: Headnote 3: gross negligent ignorance or deliberate closing of eyes is equivalent to positive knowledge for urgency; no general market monitoring obligation but specific suspicious circumstances trigger a duty to investigate.
R. 158 RoP on security for costs applies to both parties including defendants in inter partes proceedings, but not by analogy to ex parte PI proceedings given urgency character and R. 211.1(d) RoP
ClaimantLegal basis: Art. 69(4) UPCA; R. 158 RoP; R. 211.1(d) RoPNote: Headnote 4: the court rejected Curio's application for security for costs in the PI proceeding, holding R. 158 has no application (analogy or otherwise) in ex parte urgent proceedings.
security for costs should be ordered against 10x Genomics in the provisional measures proceedings
RespondentLegal basis: R. 158 RoP; R. 211.1(d) RoPReason: R. 158 RoP does not apply in ex parte provisional measures proceedings given their urgent character and R. 211.1(d) RoP.
Browse other cases on this principle.
EP 2 697 391 B1 claims arrays for spatially localised nucleic acid detection comprising a substrate with multiple capture probe types, each with a position domain and a poly-T capture domain with at least 10 deoxythymidine residues, oriented with a free 3' end as extension primer. The court confirmed that purpose language ('for use in') limits scope to arrays suitable for and intended for localised nucleic acid detection in tissue samples.