UPC CFI 463/2023
4. Dez. 2023·EP2697391 · METHOD AND PRODUCT FOR LOCALISED OR SPATIAL DETECTION OF NUCLEIC ACID IN A TISSUE SAMPLE
Hauptaktenzeichen: ACT 590953/2023
- Verfahrensdetails
- StatusCase ClosedVerfahrensartEinstweilige VerfügungKategorieEinstweilige Maßnahmen
- Parteien
- Kläger
- 10x Genomics, Inc.Unternehmen
Vertreter- Tilman Mueller-Stoy-Bardehle Pagenberg
- Martin Drews-Bardehle Pagenberg
- Axel Berger-Bardehle Pagenberg
Beklagte- Curio Bioscience Inc.Unternehmen
Vertreter- Cameron Marshall-Carpmaels & Ransford
- Agathe Michel-De Cazotte-Carpmaels & Ransford
- Cameron Marschall-Carpmaels & Ransford
- Division
- Dusseldorf LD
- Technologie
- ChemistryBiotechnology
- Sprache
- English
- Erste Entscheidung
- 29. Jan. 2024
- Letzte Entscheidung
- 30. Apr. 2024
| Einstweilige Verfügung erlassen | Median Tage bis zur ersten Entscheidung | |
|---|---|---|
| Gesamt-UPC | 54% (38/70) | 124 |
| Dusseldorf LD | Gesperrt | Gesperrt |
| Richter Ronny Thomas | Gesperrt | Gesperrt |
| Richter Berenice Thom | Gesperrt | Gesperrt |
| Richter András Kupecz | Gesperrt | Gesperrt |
| Richter Martin Schmidt | Gesperrt | Gesperrt |
Vor dem UPC: 10x Genomics, Inc. (40 Verfahren)·Curio Bioscience Inc. (19 Verfahren)
Dieser Streit umfasst 18 weitere Verfahren
UPC CFI 657/2025·UPC CFI 658/2025·UPC CoA 805/2024·UPC CoA 810/2024·UPC CoA 234/2024 und 13 weitere
Starten Sie die kostenlose Testphase, um die Ausgänge zu sehen.
Weitere Verfahren: Dusseldorf LD·2023
- 2024-04-30Application for provisional measuresÖffentlich
Zusammenfassung: The Düsseldorf Local Division granted a preliminary injunction against Curio Bioscience Inc. prohibiting it from offering, marketing, using, importing or storing arrays for spatially localised nucleic acid detection in Germany, France and Sweden, finding prima facie infringement of EP 2 697 391 B1 (owned by 10x Genomics). Both parties were ordered to pay each other interim costs of EUR 100,000. The injunction was conditional on 10x Genomics providing security of EUR 2,000,000. 10x Genomics' application for security for costs from the defendant was rejected.
Rechtsfragen anzeigen (5)
- Standing and patent register presumption under Rule 8.5(c) RoP
- Purpose-limiting claim features and scope of protection
- Urgency and knowledge of infringement in provisional measures
- Security for costs in provisional measures proceedings
- Applicability of Rule 158 RoP to defendants
- 2024-04-30
Zusammenfassung: Düsseldorf Local Division granted a preliminary injunction (30 April 2024) against Curio Bioscience Inc. ordering it to cease offering, marketing, using or possessing arrays for localised detection of nucleic acid in tissue samples in Germany, France, and Sweden that infringe EP 2 697 391. A penalty of up to EUR 100,000 per day of contravention was imposed. Enforceability was conditional on the applicant providing a security of EUR 2,000,000.
Rechtsfragen anzeigen (6)
- Provisional measures – infringement of spatial transcriptomics patent
- Patent proprietor standing (R. 8.5 RoP)
- Claim interpretation – stated purposes
- Limitation period / knowledge of infringement
- Security for costs (R. 158 RoP)
- Security for enforceability
- 2024-04-23
Zusammenfassung: Düsseldorf Local Division procedural order following the Court of Appeal's reversal of the President's language decision, directing that the language of the proceedings be changed to English before the final order on provisional measures. The order deals with Germany's R. 14.2(c) RoP indication, allowing the judges to issue decisions in German with certified English translations, and enables the provisional measures decision (in the 10x Genomics vs Curio Bioscience matter, EP 2 697 391) to be issued promptly in both languages.
Rechtsfragen anzeigen (3)
- Language of proceedings change after oral hearing (R. 14.2(c) RoP / Art. 49(2) UPCA)
- Germany's indication re bilingual decisions
- Certified translation requirement (R. 118.8 RoP)
- 2024-02-14Application for provisional measuresÖffentlich
Zusammenfassung: The Düsseldorf Local Division issued a procedural order in 10x Genomics v. Curio Bioscience establishing a structured confidentiality protection procedure under Rule 262A RoP, clarifying the CMS workflow for trade secret protection and setting out the process for granting preliminary access restrictions before a final confidentiality order is made.
Rechtsfragen anzeigen (4)
- Rule 262A RoP: confidentiality protection workflow in CMS
- Preliminary access restrictions pending final confidentiality order
- Hearing requirement before final confidentiality order (Rule 262A.4 RoP)
- Trade secret protection in interim proceedings
- 2024-01-29Application for provisional measuresÖffentlich
Zusammenfassung: The Düsseldorf Local Division issued a procedural order in the 10x Genomics v. Curio Bioscience provisional measures proceedings, deciding ex officio to appoint a technically qualified judge given the technical complexity of the patent (spatial transcriptomics), relying on Art. 8(5) UPCA even in the absence of an express provision for interim proceedings.
Rechtsfragen anzeigen (2)
- Art. 8(5) UPCA and Rule 34 RoP: appointment of technically qualified judge ex officio in provisional measures proceedings
- Patent validity as condition for provisional measures
| Dokumenttitel | Datum | Öffentlich |
|---|---|---|
| Headnote-and-Keywords | 2025-06-04 | Nicht öffentlich |
| Outcome of the Order | 2025-06-04 | Nicht öffentlich |
| Amendment of the confidentiality club | 2025-06-04 | Nicht öffentlich |
| Amendment of the confidentiality club | 2025-06-04 | Öffentlich |
| 04.06.2025 - Response to 10x request regarding 11 March 2024 confidentiality club_signed | 2025-06-04 | Nicht öffentlich |
| Opportunity to comment | 2025-05-28 | Nicht öffentlich |
| Opportunity to respond | 2025-05-28 | Nicht öffentlich |
| Receipt | 2025-05-28 | Nicht öffentlich |
| Request for extension of confidentiality club | 2025-05-28 | Nicht öffentlich |
| Headnote-and-Keywords | 2025-02-20 | Nicht öffentlich |
10x Genomics obtained a preliminary injunction before the Düsseldorf Local Division against Curio Bioscience prohibiting it from offering, marketing, using, importing or storing spatially-localised nucleic acid detection arrays in Germany, France and Sweden, finding prima facie infringement of EP 2 697 391 B1. The PI was conditional on 10x Genomics providing EUR 2,000,000 security; each party was ordered to pay the other EUR 100,000 in interim costs; Curio's application for security for costs was rejected as inapplicable in ex parte urgent proceedings.
10x Genomics has prima facie standing as registered proprietor of EP 2 697 391 B1
KlägerRechtsgrundlage: R. 8.5(c) RoPHinweis: Headnote 1: registration in the national patent register gives rise to a rebuttable presumption of entitlement; burden shifts to respondent to disprove.
prima facie infringement of EP 2 697 391 B1 (spatial transcriptomics array) by Curio Bioscience
KlägerRechtsgrundlage: Art. 62 UPCA; R. 211 RoPHinweis: Court found sufficient prima facie case to grant PI; purpose-bound claim elements (Zweckangaben) were interpreted as limiting scope to arrays suitable for the stated purpose.
purpose statements in patent claims limit the protected subject matter to items suitable for the stated purpose
KlägerRechtsgrundlage: Art. 69 EPCHinweis: Headnote 2: purpose indications in claims define the subject matter to require suitability for that purpose, not merely geometric features.
urgency established: knowledge of infringement arises from constructive knowledge where patent holder is put on notice of circumstances likely indicating infringement
KlägerRechtsgrundlage: Art. 62 UPCA; R. 211 RoPHinweis: Headnote 3: gross negligent ignorance or deliberate closing of eyes is equivalent to positive knowledge for urgency; no general market monitoring obligation but specific suspicious circumstances trigger a duty to investigate.
R. 158 RoP on security for costs applies to both parties including defendants in inter partes proceedings, but not by analogy to ex parte PI proceedings given urgency character and R. 211.1(d) RoP
KlägerRechtsgrundlage: Art. 69(4) UPCA; R. 158 RoP; R. 211.1(d) RoPHinweis: Headnote 4: the court rejected Curio's application for security for costs in the PI proceeding, holding R. 158 has no application (analogy or otherwise) in ex parte urgent proceedings.
10x Genomics has sufficient standing to bring the action based on registration in the respective national patent registers; this creates a rebuttable presumption reversing the burden of proof
KlägerRechtsgrundlage: R. 8.5(c) RoPHinweis: Court held that once applicant demonstrates registration in national registers, it is for the defendant to rebut the presumption of entitlement.
Infringement of EP 2 697 391 B1 (spatial transcriptomics array patent) by Curio Bioscience's arrays in Germany, France and Sweden
KlägerRechtsgrundlage: Art. 25(a) UPCAHinweis: Court found infringement and granted the preliminary injunction restraining Curio from offering, marketing or using the infringing spatial transcriptomics arrays in the three territories.
Stated purposes in patent claims indirectly define subject matter protected — product must not only fulfil spatial-physical features but be designed for the stated purpose
KlägerRechtsgrundlage: Art. 69 EPC; purposive claim constructionHinweis: Court accepted this purposive interpretation, which helped confirm that Curio's arrays fell within the scope of the claim.
Grossly negligent ignorance or wilful blindness to infringement is equivalent to positive knowledge for the purposes of calculating the urgency clock
KlägerRechtsgrundlage: UPC case law on knowledge of infringementHinweis: Court accepted that a patent holder who becomes aware of circumstances suggesting infringement must take readily available steps to investigate; failure to do so constitutes negligent ignorance equivalent to knowledge.
security for costs should be ordered against 10x Genomics in the provisional measures proceedings
BeklagterRechtsgrundlage: R. 158 RoP; R. 211.1(d) RoPBegründung: R. 158 RoP does not apply in ex parte provisional measures proceedings given their urgent character and R. 211.1(d) RoP.
Request to order Curio Bioscience to compensate 10x Genomics for reputational and other damages incurred as a result of the proceedings
BeklagterBegründung: Rejected by the court without detailed reasoning visible in the excerpt.
Request by 10x Genomics for defendant to provide security for anticipated litigation costs
KlägerRechtsgrundlage: Art. 69(4) EPC; R. 158 RoP; R. 211.1(d) RoPBegründung: Rejected; in urgent provisional measure proceedings, R. 211.1(d) RoP precludes the need for such security given the urgent nature of the proceedings. Art. 69(4) EPC provides security for costs only for claimant, while R. 158 RoP extends this to both parties, but in urgent proceedings there is neither scope nor need for analogous application.
Weitere Fälle zu diesem Grundsatz ansehen.
EP 2 697 391 B1 claims arrays for spatially localised nucleic acid detection comprising a substrate with multiple capture probe types, each with a position domain and a poly-T capture domain with at least 10 deoxythymidine residues, oriented with a free 3' end as extension primer. The court confirmed that purpose language ('for use in') limits scope to arrays suitable for and intended for localised nucleic acid detection in tissue samples.