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UPC CFI 463/2023

4. Dez. 2023·EP2697391 · METHOD AND PRODUCT FOR LOCALISED OR SPATIAL DETECTION OF NUCLEIC ACID IN A TISSUE SAMPLE

Hauptaktenzeichen: ACT 590953/2023

Verfahrensdetails
Status
Case Closed
Verfahrensart
Einstweilige Verfügung
Kategorie
Einstweilige Maßnahmen
Parteien
Kläger
Vertreter
Beklagte
Vertreter
Division
Dusseldorf LD
Technologie
  • Chemistry
    Biotechnology
Sprache
English
Erste Entscheidung
29. Jan. 2024
Letzte Entscheidung
30. Apr. 2024
Im Vergleich
Die Bilanz des Gerichts für diese Art von Verfahren, gezählt in erstinstanzlichen Entscheidungen. Eine Zahl in Klammern gibt an, auf wie vielen Entscheidungen eine Quote beruht.
Einstweilige Verfügung erlassenMedian Tage bis zur ersten Entscheidung
Gesamt-UPC54% (38/70)124
Dusseldorf LDGesperrtGesperrt
Richter Ronny ThomasGesperrtGesperrt
Richter Berenice ThomGesperrtGesperrt
Richter András KupeczGesperrtGesperrt
Richter Martin SchmidtGesperrtGesperrt

Vor dem UPC: 10x Genomics, Inc. (40 Verfahren)·Curio Bioscience Inc. (19 Verfahren)

Entscheidungen
  • 2024-04-30
    Application for provisional measuresÖffentlich

    Zusammenfassung: The Düsseldorf Local Division granted a preliminary injunction against Curio Bioscience Inc. prohibiting it from offering, marketing, using, importing or storing arrays for spatially localised nucleic acid detection in Germany, France and Sweden, finding prima facie infringement of EP 2 697 391 B1 (owned by 10x Genomics). Both parties were ordered to pay each other interim costs of EUR 100,000. The injunction was conditional on 10x Genomics providing security of EUR 2,000,000. 10x Genomics' application for security for costs from the defendant was rejected.

    Rechtsfragen anzeigen (5)
    • Standing and patent register presumption under Rule 8.5(c) RoP
    • Purpose-limiting claim features and scope of protection
    • Urgency and knowledge of infringement in provisional measures
    • Security for costs in provisional measures proceedings
    • Applicability of Rule 158 RoP to defendants
  • 2024-04-30

    Zusammenfassung: Düsseldorf Local Division granted a preliminary injunction (30 April 2024) against Curio Bioscience Inc. ordering it to cease offering, marketing, using or possessing arrays for localised detection of nucleic acid in tissue samples in Germany, France, and Sweden that infringe EP 2 697 391. A penalty of up to EUR 100,000 per day of contravention was imposed. Enforceability was conditional on the applicant providing a security of EUR 2,000,000.

    Rechtsfragen anzeigen (6)
    • Provisional measures – infringement of spatial transcriptomics patent
    • Patent proprietor standing (R. 8.5 RoP)
    • Claim interpretation – stated purposes
    • Limitation period / knowledge of infringement
    • Security for costs (R. 158 RoP)
    • Security for enforceability
  • 2024-04-23

    Zusammenfassung: Düsseldorf Local Division procedural order following the Court of Appeal's reversal of the President's language decision, directing that the language of the proceedings be changed to English before the final order on provisional measures. The order deals with Germany's R. 14.2(c) RoP indication, allowing the judges to issue decisions in German with certified English translations, and enables the provisional measures decision (in the 10x Genomics vs Curio Bioscience matter, EP 2 697 391) to be issued promptly in both languages.

    Rechtsfragen anzeigen (3)
    • Language of proceedings change after oral hearing (R. 14.2(c) RoP / Art. 49(2) UPCA)
    • Germany's indication re bilingual decisions
    • Certified translation requirement (R. 118.8 RoP)
  • 2024-02-14
    Application for provisional measuresÖffentlich

    Zusammenfassung: The Düsseldorf Local Division issued a procedural order in 10x Genomics v. Curio Bioscience establishing a structured confidentiality protection procedure under Rule 262A RoP, clarifying the CMS workflow for trade secret protection and setting out the process for granting preliminary access restrictions before a final confidentiality order is made.

    Rechtsfragen anzeigen (4)
    • Rule 262A RoP: confidentiality protection workflow in CMS
    • Preliminary access restrictions pending final confidentiality order
    • Hearing requirement before final confidentiality order (Rule 262A.4 RoP)
    • Trade secret protection in interim proceedings
  • 2024-01-29
    Application for provisional measuresÖffentlich

    Zusammenfassung: The Düsseldorf Local Division issued a procedural order in the 10x Genomics v. Curio Bioscience provisional measures proceedings, deciding ex officio to appoint a technically qualified judge given the technical complexity of the patent (spatial transcriptomics), relying on Art. 8(5) UPCA even in the absence of an express provision for interim proceedings.

    Rechtsfragen anzeigen (2)
    • Art. 8(5) UPCA and Rule 34 RoP: appointment of technically qualified judge ex officio in provisional measures proceedings
    • Patent validity as condition for provisional measures
DokumenttitelDatumÖffentlich
Headnote-and-Keywords2025-06-04Nicht öffentlich
Outcome of the Order2025-06-04Nicht öffentlich
Amendment of the confidentiality club2025-06-04Nicht öffentlich
Amendment of the confidentiality club2025-06-04Öffentlich
04.06.2025 - Response to 10x request regarding 11 March 2024 confidentiality club_signed2025-06-04Nicht öffentlich
Opportunity to comment2025-05-28Nicht öffentlich
Opportunity to respond2025-05-28Nicht öffentlich
Receipt2025-05-28Nicht öffentlich
Request for extension of confidentiality club2025-05-28Nicht öffentlich
Headnote-and-Keywords2025-02-20Nicht öffentlich
Abdeckung: Teilweise.Begründung teilweise extrahiert — einige Abschnitte können unvollständig sein.
Zusammenfassung in einfacher Sprache

10x Genomics obtained a preliminary injunction before the Düsseldorf Local Division against Curio Bioscience prohibiting it from offering, marketing, using, importing or storing spatially-localised nucleic acid detection arrays in Germany, France and Sweden, finding prima facie infringement of EP 2 697 391 B1. The PI was conditional on 10x Genomics providing EUR 2,000,000 security; each party was ordered to pay the other EUR 100,000 in interim costs; Curio's application for security for costs was rejected as inapplicable in ex parte urgent proceedings.

Angenommene Argumente
Was das Gericht akzeptiert hat — nach Partei.
  • 10x Genomics has prima facie standing as registered proprietor of EP 2 697 391 B1

    KlägerRechtsgrundlage: R. 8.5(c) RoP

    Hinweis: Headnote 1: registration in the national patent register gives rise to a rebuttable presumption of entitlement; burden shifts to respondent to disprove.

  • prima facie infringement of EP 2 697 391 B1 (spatial transcriptomics array) by Curio Bioscience

    KlägerRechtsgrundlage: Art. 62 UPCA; R. 211 RoP

    Hinweis: Court found sufficient prima facie case to grant PI; purpose-bound claim elements (Zweckangaben) were interpreted as limiting scope to arrays suitable for the stated purpose.

  • purpose statements in patent claims limit the protected subject matter to items suitable for the stated purpose

    KlägerRechtsgrundlage: Art. 69 EPC

    Hinweis: Headnote 2: purpose indications in claims define the subject matter to require suitability for that purpose, not merely geometric features.

  • urgency established: knowledge of infringement arises from constructive knowledge where patent holder is put on notice of circumstances likely indicating infringement

    KlägerRechtsgrundlage: Art. 62 UPCA; R. 211 RoP

    Hinweis: Headnote 3: gross negligent ignorance or deliberate closing of eyes is equivalent to positive knowledge for urgency; no general market monitoring obligation but specific suspicious circumstances trigger a duty to investigate.

  • R. 158 RoP on security for costs applies to both parties including defendants in inter partes proceedings, but not by analogy to ex parte PI proceedings given urgency character and R. 211.1(d) RoP

    KlägerRechtsgrundlage: Art. 69(4) UPCA; R. 158 RoP; R. 211.1(d) RoP

    Hinweis: Headnote 4: the court rejected Curio's application for security for costs in the PI proceeding, holding R. 158 has no application (analogy or otherwise) in ex parte urgent proceedings.

  • 10x Genomics has sufficient standing to bring the action based on registration in the respective national patent registers; this creates a rebuttable presumption reversing the burden of proof

    KlägerRechtsgrundlage: R. 8.5(c) RoP

    Hinweis: Court held that once applicant demonstrates registration in national registers, it is for the defendant to rebut the presumption of entitlement.

  • Infringement of EP 2 697 391 B1 (spatial transcriptomics array patent) by Curio Bioscience's arrays in Germany, France and Sweden

    KlägerRechtsgrundlage: Art. 25(a) UPCA

    Hinweis: Court found infringement and granted the preliminary injunction restraining Curio from offering, marketing or using the infringing spatial transcriptomics arrays in the three territories.

  • Stated purposes in patent claims indirectly define subject matter protected — product must not only fulfil spatial-physical features but be designed for the stated purpose

    KlägerRechtsgrundlage: Art. 69 EPC; purposive claim construction

    Hinweis: Court accepted this purposive interpretation, which helped confirm that Curio's arrays fell within the scope of the claim.

  • Grossly negligent ignorance or wilful blindness to infringement is equivalent to positive knowledge for the purposes of calculating the urgency clock

    KlägerRechtsgrundlage: UPC case law on knowledge of infringement

    Hinweis: Court accepted that a patent holder who becomes aware of circumstances suggesting infringement must take readily available steps to investigate; failure to do so constitutes negligent ignorance equivalent to knowledge.

Zurückgewiesene Argumente
Was das Gericht nicht akzeptiert hat — und warum.
  • security for costs should be ordered against 10x Genomics in the provisional measures proceedings

    BeklagterRechtsgrundlage: R. 158 RoP; R. 211.1(d) RoP

    Begründung: R. 158 RoP does not apply in ex parte provisional measures proceedings given their urgent character and R. 211.1(d) RoP.

  • Request to order Curio Bioscience to compensate 10x Genomics for reputational and other damages incurred as a result of the proceedings

    Beklagter

    Begründung: Rejected by the court without detailed reasoning visible in the excerpt.

  • Request by 10x Genomics for defendant to provide security for anticipated litigation costs

    KlägerRechtsgrundlage: Art. 69(4) EPC; R. 158 RoP; R. 211.1(d) RoP

    Begründung: Rejected; in urgent provisional measure proceedings, R. 211.1(d) RoP precludes the need for such security given the urgent nature of the proceedings. Art. 69(4) EPC provides security for costs only for claimant, while R. 158 RoP extends this to both parties, but in urgent proceedings there is neither scope nor need for analogous application.

Hinweise zur Anspruchsauslegung

EP 2 697 391 B1 claims arrays for spatially localised nucleic acid detection comprising a substrate with multiple capture probe types, each with a position domain and a poly-T capture domain with at least 10 deoxythymidine residues, oriented with a free 3' end as extension primer. The court confirmed that purpose language ('for use in') limits scope to arrays suitable for and intended for localised nucleic acid detection in tissue samples.