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UPC CFI 2/2023

Jun 1, 2023·EP4108782: COMPOSITIONS AND METHODS FOR ANALYTE DETECTION

Case details
Status
Case Closed
Action
Provisional measures
Category
Provisional Measures
Division
Munich LD
Technology
Biotechnology
Language
German
First decided
Jun 23, 2023
Last decision
Dec 5, 2023
Decisions
  • 2023-12-05
    Injunction grantedApplication for provisional measures

    The Munich Local Division imposed a penalty payment of EUR 100,000 on NanoString Technologies entities for non-compliance with a preliminary injunction under Article 62 UPCA, clarifying that no separate enforcement order is required under Article 82(4) UPCA and that national enforcement law requirements do not apply.

    Legal issues:Penalty payment for violation of provisional injunction (Art. 82(4) UPCA)No separate enforcement order requiredRule 118.8 RoP inapplicable to Art. 62 orders
  • 2023-09-19
    PI grantedPreliminary injunctionApplication for provisional measures

    This is the German-language version of the same Munich Local Division provisional measures decision of 19 September 2023 (EP 4 108 782), granting provisional measures to 10x Genomics/Harvard College against NanoString Technologies with substantially identical operative provisions.

    Legal issues:Provisional measures Art. 62 UPCAPrima facie validity unitary patentDelay in seeking provisional measuresIndirect patent infringement
  • 2023-09-19
    PI grantedPreliminary injunctionApplication for provisional measures

    The Munich Local Division granted provisional measures to 10x Genomics and President and Fellows of Harvard College against NanoString Technologies (EP 4 108 782 — spatial genomics), prohibiting NanoString from offering, selling or delivering MERSCOPE decoder probes, with penalty of up to EUR 250,000 per violation; the amount in dispute was set at EUR 7 million.

    Legal issues:Provisional measures Art. 62 UPCAPrima facie validity unitary patentDelay in seeking provisional measuresIndirect patent infringementEnforcement of unitary patent vs. European patent
  • 2023-07-10
    Application for provisional measures

    The Munich Local Division granted a deadline extension in the 10x Genomics/Harvard v. NanoString preliminary injunction proceedings following a request by the respondent side.

    Legal issues:Deadline extension Rule 9.3 RoP
  • 2023-07-06
    Application for provisional measures

    The Munich Local Division issued an order under Rule 7.1 RoP determining that translations of English-language exhibits were not required in the 10x Genomics/Harvard v. NanoString preliminary injunction proceedings.

    Legal issues:Translation of exhibits Rule 7.1 RoP
  • 2023-06-30
    Application for provisional measures

    The Munich Local Division issued a supplementary procedural order correcting an earlier scheduling order to require that the defence include the arguments from the protective brief (Schutzschrift) in German, the language of proceedings.

    Legal issues:Language of defenceProtective brief (Schutzschrift)Procedural correction
  • 2023-06-23
    Application for provisional measures

    The Munich Local Division issued a scheduling and briefing order for the oral hearing in 10x Genomics and Harvard's preliminary injunction application against NanoString Technologies.

    Legal issues:Preliminary injunction schedulingOral hearing
Documents
Document titleDatePublic
workflow closed2025-07-16Not public
Outcome of the Order2025-07-16Not public
rectification2025-07-16Public
Outcome of the Order2025-07-16Not public
workflow closed2025-07-16Not public
Outcome of the Order2025-07-16Not public
workflow closed2025-07-16Public
Outcome of the Order2025-07-16Not public
workflow closed2025-07-16Public
Outcome of the Order2025-07-16Not public
workflow closed2025-07-16Public
Outcome of the Order2025-07-16Not public
workflow closed2025-07-16Public
Outcome of the Order2025-07-16Not public
withdrawal and reimbursement2025-07-16Public
Outcome of the Order2025-07-16Not public
withdrawal and reimbursement2025-07-16Public
Receipt2025-05-14Not public
250514withdrawal PI damages request 9111-20252025-05-14Not public
Outcome of the Order2025-05-14Not public
deadline extension2025-05-14Public
Outcome of the Order2025-05-14Not public
deadline extension2025-05-14Public
Outcome of the Order2025-05-14Not public
deadline extension2025-05-14Public
Outcome of the Order2025-05-14Not public
deadline extension2025-05-14Public
Receipt2025-05-13Not public
Receipt2025-05-13Not public
Receipt2025-05-13Not public
Receipt2025-05-13Not public
Time extension - Request of 10x Genomics2025-05-12Not public
Time extension - Request of 10x Genomics2025-05-12Not public
Time extension - Request of 10x Genomics2025-05-12Not public
Time extension - Request of 10x Genomics2025-05-12Not public
Receipt2025-05-08Not public
AG-C2-FTI-172025-05-07Not public
AG-C2-FTI-182025-05-07Not public
AG-C2-FTI-72025-05-07Not public
AG-C2-FTI-232025-05-07Not public
AG-C2-FTI-52025-05-07Not public
AG-C2-FTI-132025-05-07Not public
AG-C2-FTI-92025-05-07Not public
AG-C2-FTI-162025-05-07Not public
AG-C2-FTI-62025-05-07Not public
AG-C2-FTI-192025-05-07Not public
Annex AG-C 22025-05-07Not public
AG-C2-FTI-202025-05-07Not public
AG-C2-FTI-222025-05-07Not public
AG-C2-FTI-142025-05-07Not public
250507 Submission re Confidentiality R. 262.2 re 9459-2025 and 9111_2025.signed2025-05-07Not public
Annex AG-C 12025-05-07Not public
AG-C2-FTI-32025-05-07Not public
AG-C2-FTI-12025-05-07Not public
AG-C2-FTI-82025-05-07Not public
AG-C2-FTI-22025-05-07Not public
AG-C2-FTI-152025-05-07Not public
AG-C2-FTI-102025-05-07Not public
AG-C2-FTI-122025-05-07Not public
AG-C2-FTI-42025-05-07Not public
AG-C2-FTI-212025-05-07Not public
AG-C2-FTI-112025-05-07Not public
Comments party change request2025-05-02Not public
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Comments party change request2025-05-02Not public
Receipt2025-04-28Not public
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250428 party change request - 9111/20252025-04-28Not public
250428 party change request - 9111/20252025-04-28Not public
250428 party change request - 9111/20252025-04-28Not public
250428 party change request - 9111/20252025-04-28Not public
Outcome of the Order2025-04-17Not public
continuation of proceedings2025-04-17Public
Outcome of the Order2025-04-17Not public
continuation of proceedings2025-04-17Public
Outcome of the Order2025-04-17Not public
continuation of proceedings2025-04-17Public
continuation of proceedings2025-04-17Public
250411 Stn. an UPC re Aussetzung - 16254-20252025-04-11Not public
250411 Stn. an UPC re Aussetzung - 16254-20252025-04-11Not public
250411 Stn. an UPC re Aussetzung - 16254-20252025-04-11Not public
Stellungnahme Aussetzungsantrag2025-04-09Not public
Receipt2025-04-07Not public
Exhibit BP-SE012025-04-03Not public
Exhibit BP-SE022025-04-03Not public
Application for a stay_10x2025-04-03Not public
Exhibit BP-SE032025-04-03Not public
250402 Stn. an UPC2025-04-02Not public
250402 Stn. an UPC2025-04-02Not public
250402 Stn. an UPC2025-04-02Not public
Stellungnahme bzgl. Verfahrenssprache - 10x2025-04-01Not public
Stellungnahme bzgl. Verfahrenssprache - 10x2025-04-01Not public
Receipt2025-03-25Not public
R. 353 RoP Application2025-03-24Not public
Outcome of the Order2025-03-20Not public
Weitere Stellungnahme App_9459-20252025-03-20Public
Weitere Stellungnahme App_9459-20252025-03-20Not public
Receipt2025-03-19Not public
Regel 9 Antrag 10x.2025-03-18Not public
Stellungnahme zum Antrag App_12922-20252025-03-18Not public
Receipt2025-03-17Not public
Submission2025-03-14Not public
Submission2025-03-14Not public
250314 Antrag auf Wechsel der Verfahrenssprache2025-03-14Not public
Stellungnahme Antrag Vertraulichkeitsschutz2025-02-28Not public
Receipt2025-02-26Not public
Zahlungsbeleg damages claim - 9111/20252025-02-25Not public
250225 Geheimhaltung 262A re 9111-2025 - 9459-2025.signed2025-02-25Not public
AG-SE 11 - FTI-42025-02-25Not public
AG-SE 11 - FTI-42025-02-25Not public
AG-SE 11 -FTI-14.pdf2025-02-25Not public
AG-SE 11 - FTI-212025-02-25Not public
AG-SE 11 - FTI-232025-02-25Not public
AG-SE 11 - FTI-52025-02-25Not public
AG-SE 11 -FTI-17.pdf2025-02-25Not public
AG-SE 11 - FTI 82025-02-25Not public
AG-SE 11 - FTI-62025-02-25Not public
AG-SE 11 - FTI-202025-02-25Not public
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AG-SE 11 - FTI-192025-02-25Not public
AG-SE 11 -FTI-11.pdf2025-02-25Not public
AG-SE 92025-02-25Not public
AG-SE 11 - FTI-72025-02-25Not public
AG-SE 11 - FTI-12025-02-25Not public
AG-SE 11 -FTI-2.pdf2025-02-25Not public
AG-SE 72025-02-25Not public
AG-SE 22025-02-25Not public
AG-SE 11 - FTI-222025-02-25Not public
AG-SE 11 - FTI-222025-02-25Not public
AG-SE 11 - FTI-192025-02-25Not public
AG-SE 32025-02-25Not public
AG-SE 11 - FTI-72025-02-25Not public
AG-SE - FTI-32025-02-25Not public
AG-SE 11 -FTI-12.pdf2025-02-25Not public
AG-SE 11 - FTI-62025-02-25Not public
AG-SE 11 - FTI-212025-02-25Not public
AG-SE 11 -FTI-15.pdf2025-02-25Not public
AG-SE 102025-02-25Not public
AG-SE 11 -FTI-13.pdf2025-02-25Not public
AG-SE 11 - FTI 82025-02-25Not public
AG-SE 52025-02-25Not public
2025-02-25 GER PI damages claim.signed2025-02-25Not public
AG-SE 11 - FTI-182025-02-25Not public
AG-SE 11 - FTI-182025-02-25Not public
AG-SE - FTI-32025-02-25Not public
AG-SE 11 - FTI-202025-02-25Not public
AG-SE 11 - FTI-232025-02-25Not public
AG-SE 82025-02-25Not public
AG-SE 112025-02-25Not public
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AG-SE 11 - FTI-52025-02-25Not public
AG-SE 11 - FTI-102025-02-25Not public
AG-SE 11 - FTI-92025-02-25Not public
AG-SE 62025-02-25Not public
AG-SE 11 - FTI-92025-02-25Not public
AG-SE 11 -FTI-16.pdf2025-02-25Not public
AG-SE 11 - FTI-102025-02-25Not public
AG-SE 42025-02-25Not public
Outcome of the Order2025-02-24Not public
Entscheidung Kostenfestsetzung2025-02-24Public
Outcome of the Order2025-01-14Not public
Parteiersetzung2025-01-14Public
Outcome of the Order2025-01-14Not public
Parteiersetzung2025-01-14Public
Outcome of the Order2025-01-14Not public
Parteiersetzung2025-01-14Public
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Parteiersetzung2025-01-14Public
Receipt2025-01-14Not public
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Receipt2025-01-14Not public
251001 EP782 UPC Partie change request PI cost request - 15954-20242025-01-13Not public
251001 EP782 UPC Partie change request PI cost request - 15954-20242025-01-13Not public
251001 EP782 UPC Partie change request PI cost request - 15954-20242025-01-13Not public
251001 EP782 UPC Partie change request PI cost request - 15954-20242025-01-13Not public
Stellungnahme - Harvard2024-12-20Not public
Stellungnahme - 10x Genomics2024-12-20Not public
Stellungnahme Kostenfestsetzung2024-12-06Not public
Signiert 241206 re VerfAO re PI costs - 459746-20232024-12-06Not public
Exhibit USA3 1_24bk10160_ NS Wind Down Co._ Inc2024-12-06Not public
Signiert 241206 re VerfAO re PI costs - 459746-20232024-12-06Not public
Exhibit USA3 1_24bk10160_ NS Wind Down Co._ Inc2024-12-06Not public
Exhibit USA3 1_24bk10160_ NS Wind Down Co._ Inc2024-12-06Not public
Signiert 241206 re VerfAO re PI costs - 459746-20232024-12-06Not public
Fortsetzung Kostenfestsetzungsverfahren2024-12-03Not public
Outcome of the Order2024-11-13Not public
Kenntnisnahme Schriftsatz2024-11-13Public
Anlage2024-08-14Not public
240814 Stn. Kostenentscheidung - 459746-20232024-08-14Not public
Anlage2024-08-14Not public
240814 Stn. Kostenentscheidung - 459746-20232024-08-14Not public
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240814 Stn. Kostenentscheidung - 459746-20232024-08-14Not public
Weiteres Vorgehen Kostenentscheidung2024-07-25Not public
Outcome of the Order2024-07-25Not public
Verfahrensfortsetzung2024-07-25Public
Schriftsatz2024-07-22Not public
Schriftsatz2024-07-22Not public
Stellungnahme Verfahrensfortsetzung2024-07-11Not public
Receipt2024-05-13Not public
240513 Kosten Berufung2024-05-13Not public
Anlage USA 42024-05-13Not public
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240425 SS Kosten Berufung UPC re Bruker - 459746-2023.signiert2024-04-25Not public
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Stellungnahme Antrag 26-03-20242024-03-26Not public
Receipt2024-03-26Not public
Anlage USA 12024-03-26Not public
240326 Kosten Berufung2024-03-26Not public
Anlage USA 22024-03-26Not public
Outcome of the Order2023-12-12Not public
Kenntnisnahme Schriftsatz2023-12-12Not public
Outcome of the Order2023-12-05Not public
Entscheidung Zwangsgeldantrag2023-12-05Not public
Outcome of the Order2023-12-05Not public
Terminsbestimmung2023-12-05Not public
Receipt2023-12-04Not public
231204 SS an UPC re Aufzeichnung mV - 459746-2023 - signiert2023-12-04Not public
Receipt2023-11-30Not public
Schriftsatz2023-11-30Not public
BP ZV 132023-11-30Not public
Schriftsatz2023-10-16Not public
Anlage B-ZG 52023-10-16Not public
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Weitere Stellungnahme2023-10-16Not public
Erwiderung2023-10-11Not public
BP ZV 112023-10-11Not public
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BP ZV 112023-10-11Not public
Erwiderung2023-10-11Not public
BP ZV 122023-10-11Not public
Anlage B-ZG 12023-10-06Not public
06-10-2023 signiert UPC Erwiderung Zwangsgeld - 459746-20232023-10-06Not public
Anlage B-ZG 42023-10-06Not public
Anlage B-ZG 32023-10-06Not public
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06-10-2023 signiert UPC Erwiderung Zwangsgeld - 459746-20232023-10-06Not public
Anlage B-ZG 22023-10-06Not public
Anlage B-ZG 32023-10-06Not public
Anlage B-ZG 42023-10-06Not public
Anlage B-ZG 12023-10-06Not public
06-10-2023 signiert UPC Erwiderung Zwangsgeld - 459746-20232023-10-06Not public
Stellungnahme Zwangsgeldantrag2023-09-29Not public
Receipt2023-09-29Not public
Zwangsgeldantrag2023-09-28Not public
BP ZV 062023-09-28Not public
BP ZV 082023-09-28Not public
BP ZV 10a2023-09-28Not public
BP ZV 102023-09-28Not public
BP ZV 042023-09-28Not public
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BP ZV 022023-09-28Not public
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BP ZV 052023-09-28Not public
irrtümlich eröffneter Workflow wird geschlossen (ORD_535665_2023)2023-09-20Not public
irrtümlich eröffneter Workflow geschlossen (ORD_528423_2023)2023-09-20Not public
Outcome of the Order2023-09-20Not public
Entscheidung und Anordnungen2023-09-20Not public
Measures_DecisionOutcome_Notification.pdf2023-09-20Not public
Entscheidung und Anordnungen2023-09-20Not public
Hearing Reference 19/09/2023 (Announcement Hearing)2023-09-20Not public
Hearing Reference 06/09/20232023-09-20Not public
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Hearing Reference 19/09/2023 (Announcement Hearing)2023-09-20Not public
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summons2023-09-18Not public
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Formal-checks_Notification-of-positive-outcome2023-09-13Not public
Formal-checks_Notification-of-positive-outcome2023-09-13Not public
Schriftsatz2023-09-13Not public
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Anordnung2023-09-13Not public
Template-Order2023-09-13Not public
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Formal-checks_Notification-of-positive-outcome2023-08-30Not public
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BP 50 Teil 32023-08-30Not public
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Schriftsatz2023-08-30Not public
BP 50 Teil 22023-08-30Not public
Acknowledgement-of-lodging2023-08-24Not public
230824 SS an UPC re weitere AG - 459746-20232023-08-24Not public
Acknowledgement-of-lodging2023-08-24Not public
230824 SS an UPC re weitere AG - 459746-20232023-08-24Not public
Acknowledgement-of-lodging2023-08-24Not public
Anlage B19 - Utilization Report mit Eingangsvermerk2023-08-24Not public
Anlage B17 - Beechem UPC declaration2023-08-24Not public
Anlage B16 - Schreiben 08-08-20232023-08-24Not public
Anlage B22 - Europaeischer Recherchebericht2023-08-24Not public
eSIGNED 230824 Duplik an UPC - 459746-20232023-08-24Not public
Anlage B18 - Zweites Gutachten Contreras2023-08-24Not public
Anlage B25 - Gutachten Stierle2023-08-24Not public
Anlage B23 - Stellungnahme des EPA2023-08-24Not public
Anlage B20 - Berufungsbegruendung - 6 U 2360-232023-08-24Not public
Anlage B24 - SE report EP9282023-08-24Not public
Anlage B21 - THEREBY _ Bedeutung2023-08-24Not public
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Acknowledgement-of-adding-a-missing-party-or-Applicant2023-08-04Not public
B01-Teil 1-Seiten 331-3652023-07-24Not public
Anlage D29 - Gutachten Dr. Furneaux - Teil 12023-07-24Not public
B01 - Teil 2 - Seite 101-2002023-07-24Not public
B01 - Teil 2 - Seite 281-3002023-07-24Not public
D26 - Henegariu 19992023-07-24Not public
D02 - EP 3 425 063 A12023-07-24Not public
B01 - Teil 2 - Seite 1-502023-07-24Not public
D12 - US 2010_151472 A12023-07-24Not public
D04 - US 2011_61579265 (prio)2023-07-24Not public
B01 - Teil 2 - Seite 331-4102023-07-24Not public
B01 - Teil 2 - Seite 301-3302023-07-24Not public
Anlage D29 - Gutachten Dr. Furneaux - Teil 22023-07-24Not public
D01 - EP4108782 Druckexemplar2023-07-24Not public
B01-Teil 1-Seiten 1-252023-07-24Not public
B01-Teil 1-Seiten 245-2802023-07-24Not public
B01-Teil 1-Seiten 366-3852023-07-24Not public
B03 - D.I. 135 NanoString Reply Brief ISO MTA2023-07-24Not public
Anlage B15 US-Gerichtsbeschluss vom 10.07.20232023-07-24Not public
D20 - Hybridisation Auszug Oxford Dictionary 20062023-07-24Not public
Anlage B13 - US-Schriftsatz vom 23.05.20232023-07-24Not public
D25 - Bottari et al. 20062023-07-24Not public
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Schriftsatz2023-06-28Not public
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Acknowledgement of access to case2023-06-23Not public
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Ladung zur mündlichen Verhandlung/Fristsetzung2023-06-23Not public
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Plain-English summary

10x Genomics and President and Fellows of Harvard College obtained provisional measures against NanoString Technologies before the Munich Local Division for infringement of unitary patent EP 4108782 covering spatial genomics analyte detection methods. The court found preponderant likelihood of validity and infringement, and granted an injunction against MERSCOPE decoder probes covering both direct and indirect infringement, with EUR 250,000-per-violation penalties. In subsequent penalty proceedings, the court imposed a EUR 100,000 penalty for NanoString's failure to promptly update its website in compliance with the order, clarifying that no separate enforcement order is needed under Art. 82(4) UPCA for Art. 62 provisional measures.

Accepted arguments
What the court agreed with — by party.
  • Prima facie validity of unitary patent EP 4108782 established at preponderant likelihood standard

    ClaimantLegal basis: Art. 62 UPCA

    Note: No relevant prior art was presented by NanoString; court found preponderant likelihood of validity sufficient.

  • NanoString MERSCOPE decoder probes directly and indirectly infringe EP 4108782 (spatial genomics method patent)

    ClaimantLegal basis: Art. 62 UPCA; Art. 64 UPCA

    Note: Court found both direct infringement by applying the patented method and indirect infringement through supply of decoder probes as essential components.

  • Urgency: enforcement of European patent without unitary effect in all member states separately is not an equivalent remedy to UPC enforcement; delay assessed from when UPC enforcement became possible

    ClaimantLegal basis: Art. 62 UPCA

    Note: Court accepted that prior national enforcement steps do not amount to unreasonable delay for UPC provisional measures purposes.

Rejected arguments
What the court did not agree with — and why.
  • Applicants delayed unreasonably in seeking provisional measures

    RespondentLegal basis: Art. 62 UPCA

    Reason: Delay must be assessed from when infringement became known and from when UPC enforcement was available; prior enforcement of European patents nationally is not equivalent and does not start the delay clock for UPC measures.

Claim construction notes

The Munich Local Division construed claim 1 of EP 4108782 (a spatial genomics method for analyte detection using decoder probes). The court found that NanoString's MERSCOPE decoder probes fell within the claim scope for both direct and indirect infringement. The court also addressed indirect infringement, finding that decoder probes are essential components for application of the patented method.