UPC CFI 437/2024
Jul 25, 2024·EP3346403 · DATA PROCESSING, ANALYSIS METHOD OF GENE EXPRESSION DATA TO IDENTIFY ENDOGENOUS REFERENCE GENES
- Case details
- StatusCase Closed (No infringement)ActionInfringementCategoryMain infringement action
- Parties
- Claimants
- GXD-Bio CorporationOther / unknown
Representatives- Georg Rauh-Vossius & Brinkhof UPC Litigators
Respondents- Myriad International GmbHOperating co.
- Myriad GmbHOperating co.
- Myriad Service GmbHOperating co.
- Myriad Genetics GmbHOperating co.
- Myriad Genetics S.A.S.Operating co.
- Myriad Genetics B.V.Operating co.
- Myriad Genetics S.r.l.Operating co.
- Myriad Genetics, Inc.Operating co.
- Eurobio ScientificOperating co.
Representatives- Niels Hoelder-Hoffmann Eitle
- Division
- Munich LD
- Technology
- Electrical engineeringComputer technology
- ChemistryBiotechnology
- Language
- English
- First decided
- Dec 19, 2025
| Infringement found | Median days to first decision | |
|---|---|---|
| All UPC | 53% (62/117) | 124 |
| Munich LD | Locked | Locked |
| Judge Daniel Voss | Locked | Locked |
| Judge Georg Werner | Locked | Locked |
| Judge Marije Knijff | Locked | Locked |
| Judge Cornelis Schüller | — | Locked |
At the UPC: GXD-Bio Corporation (8 cases)·Myriad Genetics Group (8 cases)
This dispute contains 7 other proceedings
UPC CoA 32/2026·UPC CoA 33/2026·UPC CFI 192/2026·UPC CFI 195/2026·UPC CFI 681/2024 and 2 more
- 2025-12-19Counterclaim for revocationPublic
Summary: The Munich Local Division dismissed both the infringement action (UPC_CFI_437/2024) brought by GXD-Bio Corporation and the counterclaim for revocation (UPC_CFI_681/2024) brought by the Myriad defendants, concerning EP 3 346 403 (a patent on data processing/gene expression analysis for identifying endogenous reference genes). The Court found no infringement because the accused products (Myriad test kits) did not use the claimed three-step normalization method — the products used a single-step average normalization that differed from the patented calculation method. The counterclaim for revocation was also dismissed, so the patent was maintained. Each party bears its own costs, with costs capped at EUR 600,000 total.
Show the legal issues (5)
- Direct and indirect patent infringement
- Claim construction of normalization method
- Timeliness of evidence under R. 9.2 RoP
- Counterclaim for revocation
- Patent amendment auxiliary requests
| Document title | Date | Public |
|---|---|---|
| Order | 2026-01-21 | Not public |
| Order | 2026-01-21 | Not public |
| Receipt | 2026-01-19 | Not public |
| Cover sheet | 2026-01-19 | Not public |
| Exhibit document Applicant | 2026-01-19 | Not public |
| Application document Applicant | 2026-01-19 | Not public |
| Decision | 2025-12-19 | Public |
| Case closed | 2025-12-19 | Not public |
| Decision | 2025-12-19 | Not public |
| Decision | 2025-12-19 | Not public |
| Other Documents | 2025-11-24 | Not public |
| Cover sheet | 2025-11-14 | Not public |
| Other document Defendant | 2025-11-14 | Not public |
| Exhibit document Defendant | 2025-11-14 | Not public |
| Receipt | 2025-11-14 | Not public |
| Order | 2025-11-11 | Not public |
| Order | 2025-11-11 | Not public |
| Communication | 2025-10-13 | Not public |
| Summons to oral hearing | 2025-09-24 | Not public |
| Order | 2025-09-24 | Not public |
| Acknowledgement-of-lodging | 2025-03-31 | Not public |
| Rejoinder | 2025-03-31 | Not public |
| Acknowledgement-of-lodging | 2025-03-31 | Not public |
| HE 31 | 2025-03-31 | Not public |
| HE 26H | 2025-03-31 | Not public |
| HE 26 | 2025-03-31 | Not public |
| HE 30 | 2025-03-31 | Not public |
| HE 26E | 2025-03-31 | Not public |
| HE 26G | 2025-03-31 | Not public |
| HE 25a | 2025-03-31 | Not public |
| HE 27 | 2025-03-31 | Not public |
| HE 29 | 2025-03-31 | Not public |
| Rejoinder | 2025-03-31 | Not public |
| HE 32 | 2025-03-31 | Not public |
| HE 28 | 2025-03-31 | Not public |
| HE 26F | 2025-03-31 | Not public |
| HE 26C | 2025-03-31 | Not public |
| HE 26D | 2025-03-31 | Not public |
| Panel-Appointment | 2025-03-25 | Not public |
| Hearing-Dates | 2025-02-27 | Not public |
| Date oral hearing | 2025-02-27 | Public |
| Hearing-Dates | 2025-02-27 | Not public |
| infringement and counterclaim | 2025-02-25 | Public |
| Comments on Procedural Order | 2025-02-21 | Not public |
| Invitation to comment | 2025-02-20 | Not public |
| Headnote-and-Keywords | 2025-02-14 | Not public |
| Preliminary_Objection_DecisionOutcome | 2025-02-14 | Not public |
| Preliminary objection | 2025-02-14 | Public |
| Reply re Preliminary Objection | 2025-01-29 | Not public |
| Reply re Preliminary Objection | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Acknowledgement-of-lodging | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Exhibit VB47 | 2025-01-29 | Not public |
| Exhibit VB41 | 2025-01-29 | Not public |
| Exhibit VB45 | 2025-01-29 | Not public |
| Exhibit VB54 | 2025-01-29 | Not public |
| Exhibit VB38 | 2025-01-29 | Not public |
| Exhibit VB36 | 2025-01-29 | Not public |
| Exhibit VB43 | 2025-01-29 | Not public |
| Exhibit VB39 | 2025-01-29 | Not public |
| Exhibit VB44 | 2025-01-29 | Not public |
| Exhibit VB37 | 2025-01-29 | Not public |
| Exhibit VB46 | 2025-01-29 | Not public |
| Exhibit VB42 | 2025-01-29 | Not public |
| Exhibit VB40 | 2025-01-29 | Not public |
| Exhibit VB34 | 2025-01-29 | Not public |
| Exhibit VB35 | 2025-01-29 | Not public |
| Reply to Statement of defense | 2025-01-29 | Not public |
| Exhibit VB48 | 2025-01-29 | Not public |
| Exhibit VB49 | 2025-01-29 | Not public |
| Exhibit VB51 | 2025-01-29 | Not public |
| Exhibit VB50 | 2025-01-29 | Not public |
| Exhibit VB53 | 2025-01-29 | Not public |
| Exhibit VB52 | 2025-01-29 | Not public |
| Stellungnahmemöglichkeit | 2025-01-15 | Not public |
| Outcome of the Order | 2025-01-02 | Not public |
| Extension of time period | 2025-01-02 | Public |
| Receipt | 2024-12-27 | Not public |
| Application for extension of term for reply to SoD and Counterclaim for Revocation | 2024-12-23 | Not public |
| Headnote-and-Keywords | 2024-11-26 | Not public |
| Outcome of the Order | 2024-11-26 | Not public |
| Security | 2024-11-26 | Public |
| Response to request for provision of security for costs of proceedings | 2024-11-19 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Acknowledgement-of-lodging | 2024-11-11 | Not public |
| Statement of Defence and Counterclaim for Revocation | 2024-11-11 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-11-11 | Not public |
| Acknowledgement-of-lodging | 2024-11-08 | Not public |
| 241108 Statement of Defence_sig | 2024-11-08 | Not public |
| Acknowledgement-of-lodging | 2024-11-08 | Not public |
| 241108 Statement of Defence_sig | 2024-11-08 | Not public |
| Acknowledgement-of-lodging | 2024-11-08 | Not public |
| 241108 Statement of Defence_sig | 2024-11-08 | Not public |
| Acknowledgement-of-lodging | 2024-11-08 | Not public |
| 241108 Statement of Defence_sig | 2024-11-08 | Not public |
| Acknowledgement-of-lodging | 2024-11-08 | Not public |
| 241108 Statement of Defence_sig | 2024-11-08 | Not public |
| Acknowledgement-of-lodging | 2024-11-08 | Not public |
| 241108 Statement of Defence_sig | 2024-11-08 | Not public |
| Acknowledgement-of-lodging | 2024-11-08 | Not public |
| 241108 Statement of Defence_sig | 2024-11-08 | Not public |
| Acknowledgement-of-lodging | 2024-11-08 | Not public |
| 241108 Statement of Defence_sig | 2024-11-08 | Not public |
| HE 18 - Genexpressionstest Wikipedia | 2024-11-08 | Not public |
| HE 5a - Translation (EN) | 2024-11-08 | Not public |
| HE 15 - Dropping the OAZ1 Reference Gene from the EndoPredict Algorithm | 2024-11-08 | Not public |
| HE 10 - WitnessStatement_241108 | 2024-11-08 | Not public |
| HE 19 -Sinn et al | 2024-11-08 | Not public |
| HE 8 - Feature breakdown of claim 1 | 2024-11-08 | Not public |
| HE 14 - Smith et al | 2024-11-08 | Not public |
| HE 20 - Mullins et al | 2024-11-08 | Not public |
| HE 21 - Emails | 2024-11-08 | Not public |
| HE 5 - Prio KR 10-2006-0134883 | 2024-11-08 | Not public |
| HE 6 - Vandesompele et al | 2024-11-08 | Not public |
| HE 7b - Vandesompele et al | 2024-11-08 | Not public |
| HE 16 - De Jonge et al | 2024-11-08 | Not public |
| HE 22 - Email 26.09.2024 | 2024-11-08 | Not public |
| HE 23 - Andre et al | 2024-11-08 | Not public |
| HE 25 - AGO Guidelines | 2024-11-08 | Not public |
| HE 13 - Tramm et al | 2024-11-08 | Not public |
| HE 4 - WO 2008078969 A1 | 2024-11-08 | Not public |
| HE 7 - Declaration Prof Vandesompele | 2024-11-08 | Not public |
| HE 17 - Paik et al | 2024-11-08 | Not public |
| HE 12 - Kwon et al | 2024-11-08 | Not public |
| HE 11 - Applicants submission of December 20 2018 | 2024-11-08 | Not public |
| HE 7a - CV Prof. Vandesompele | 2024-11-08 | Not public |
| HE 9 - Klein et al | 2024-11-08 | Not public |
| HE 3 - EP17194976NWA1 | 2024-11-08 | Not public |
| HE 24 - Sestak et al | 2024-11-08 | Not public |
| Invitation to comment | 2024-11-05 | Not public |
| Receipt | 2024-11-04 | Not public |
| HE 2 | 2024-11-03 | Not public |
| Request for provision of security | 2024-11-03 | Not public |
| HE 1 | 2024-11-03 | Not public |
| Acknowledgement of access to case | 2024-10-31 | Not public |
| commentPreliminaryObjection | 2024-09-26 | Not public |
| VB29 | 2024-09-26 | Not public |
| Response to Preliminary Objection | 2024-09-26 | Not public |
| VB31 | 2024-09-26 | Not public |
| VB32 | 2024-09-26 | Not public |
| VB30 | 2024-09-26 | Not public |
| VB33 | 2024-09-26 | Not public |
| Outcome of the Order | 2024-09-24 | Not public |
| Closing of the workflow | 2024-09-24 | Public |
| preliminaryObjection | 2024-09-24 | Not public |
| Preliminary Objection | 2024-09-16 | Not public |
| Notification Of Service | 2024-09-12 | Not public |
| Zustellbestätigung | 2024-09-12 | Not public |
| Notification Of Service | 2024-09-12 | Not public |
| Zustellbestätigung | 2024-09-12 | Not public |
| Receipt | 2024-09-12 | Not public |
| Preliminary Objection | 2024-09-09 | Not public |
| Acknowledgement of access to case | 2024-09-03 | Not public |
| Acknowledgement of access to case | 2024-09-03 | Not public |
| Acknowledgement of access to case | 2024-09-03 | Not public |
| Acknowledgement of access to case | 2024-09-03 | Not public |
| Acknowledgement of access to case | 2024-09-03 | Not public |
| Acknowledgement of access to case | 2024-09-03 | Not public |
| Acknowledgement of access to case | 2024-09-03 | Not public |
| Acknowledgement of access to case | 2024-09-02 | Not public |
| Notification Of Service | 2024-08-29 | Not public |
| Proof of service | 2024-08-29 | Not public |
| Notification Of Service | 2024-08-26 | Not public |
| Postal Service | 2024-08-26 | Not public |
| Notification Of Service | 2024-08-26 | Not public |
| Postal Service | 2024-08-26 | Not public |
| Notification Of Service | 2024-08-20 | Not public |
| Proof of service | 2024-08-20 | Not public |
| Proof of service | 2024-08-13 | Not public |
| Notification Of Service | 2024-08-13 | Not public |
| Notification Of Service | 2024-08-13 | Not public |
| Proof of service | 2024-08-13 | Not public |
| Notification Of Service | 2024-08-13 | Not public |
| Proof of service | 2024-08-13 | Not public |
| Panel-Appointment | 2024-08-06 | Not public |
| epoUploadDocumentsWorkflow | 2024-08-01 | Not public |
| Document from EPO | 2024-08-01 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Letter for Service | 2024-07-29 | Not public |
| Panel-Appointment | 2024-07-29 | Not public |
| EPO-Request-for-case-pending | 2024-07-26 | Not public |
| Receipt | 2024-07-26 | Not public |
| Formal-checks_Notification-of-positive-outcome | 2024-07-26 | Not public |
| Acknowledgement-of-lodging | 2024-07-24 | Not public |
| Exhibit VB27 | 2024-07-24 | Not public |
| Exhibit VB25 | 2024-07-24 | Not public |
| Exhibit VB15 | 2024-07-24 | Not public |
| Exhibit VB21 | 2024-07-24 | Not public |
| Exhibit VB11 | 2024-07-24 | Not public |
| Exhibit VB13 | 2024-07-24 | Not public |
| Exhibit VB09 | 2024-07-24 | Not public |
| Exhibit VB08 | 2024-07-24 | Not public |
| Exhibit VB02 | 2024-07-24 | Not public |
| Exhibit VB28 | 2024-07-24 | Not public |
| Exhibit VB04 | 2024-07-24 | Not public |
| Exhibit VB16 | 2024-07-24 | Not public |
| Exhibit VB12 | 2024-07-24 | Not public |
| Exhibit VB05.2 | 2024-07-24 | Not public |
| Exhibit VB20 | 2024-07-24 | Not public |
| Statement of Claim | 2024-07-24 | Not public |
| Exhibit VB07 | 2024-07-24 | Not public |
| Exhibit VB06 | 2024-07-24 | Not public |
| Exhibit VB02.2 | 2024-07-24 | Not public |
| Exhibit VB14 | 2024-07-24 | Not public |
| Exhibit VB01 | 2024-07-24 | Not public |
| Exhibit VB26 | 2024-07-24 | Not public |
| Exhibit VB02.1 | 2024-07-24 | Not public |
| Exhibit VB05a | 2024-07-24 | Not public |
| Exhibit VB18 | 2024-07-24 | Not public |
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| Exhibit VB17 | 2024-07-24 | Not public |
| Exhibit VB19 | 2024-07-24 | Not public |
| Exhibit VB22 | 2024-07-24 | Not public |
| Exhibit VB05.1 | 2024-07-24 | Not public |
| Exhibit VB23 | 2024-07-24 | Not public |