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UPC CoA 528/2024

Sep 13, 2024·EP3666797 · ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)

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Case details
Status
Case Closed (Patent upheld as granted)
Action
Appeal
Category
Main appeal
Parties
Claimants
Representatives
Respondents
Representatives
Division
Court of Appeal
Judges
Technology
  • Chemistry
    Biotechnology · Pharmaceuticals
Language
English
First decided
Nov 25, 2025
Last decision
Mar 25, 2026
EPO Opposition
How this compares
How long the court takes to reach a first decision.
Median days to first decision
All UPC124
Judge Klaus GrabinskiLocked
Judge Nathalie SabotierLocked
Judge Peter BlokLocked

At the UPC: Amgen Group (19 cases)·Sanofi Group (33 cases)

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Related cases
All proceedings on this patent

This dispute contains 3 other proceedings

UPC CFI 2220/2025·UPC CFI 14/2023·UPC CFI 1/2023

3 other defendants litigating the same or a related patent

UPC CFI 2221/2025·UPC CoA 529/2024·CC 586764/2023

Start a free trial to see how each one ended.

More cases: Court of Appeal·2024

Decisions
  • 2026-03-25
    Withdrawal (RoP265)Public

    Summary: Sanofi and Regeneron withdrew their application for rehearing (R.245 RoP) concerning the Court of Appeal's decision of 25 November 2025 (UPC_CoA_528/2024 and UPC_CoA_529/2024) which had rejected the revocation of EP 3 666 797 and set aside the Central Division Munich's first-instance decision. The application for withdrawal was permitted. The decision covers both UPC_CoA_528/2024 and UPC_CoA_529/2024. Court fees were to be reimbursed accordingly.

    Show the legal issues (2)
    • Withdrawal of application for rehearing under R.245 RoP
    • Reimbursement of court fees under R.370.9 RoP
  • 2026-02-18
    Public

    Summary: The Court of Appeal (Panel with Klaus Grabinski, Nathalie Sabotier, Peter Blok) rejected Sanofi and Regeneron's application for suspensive effect concerning the Court of Appeal's own decision of 25 November 2025 which had rejected the requests for revocation of EP 3 666 797. Sanofi and Regeneron sought suspensive effect as part of a petition for rehearing (R. 220.4 RoP). The court found no basis to suspend a revocation-rejection decision (as this had no practical effect on the patent's validity status), and rejected the claim that the CoA's reasoning on claim interpretation and inventive step was based on issues not argued by the parties.

    Show the legal issues (4)
    • Suspensive effect in connection with petition for rehearing (R. 220.4 RoP)
    • Revocation action - patent maintained by CoA on appeal
    • Right to be heard (ultra petita) in appeal proceedings
    • Suspensive effect of revocation appeal (Art. 74(2) UPCA)
  • 2025-11-25
    Appeal RoP220.1Public

    Summary: The Court of Appeal allowed Amgen's appeals in the revocation action and counterclaim for revocation concerning the PCSK9 antibody patent (Amgen v Sanofi and Regeneron). It set aside the Munich Central Division's decision revoking the patent, rejected the requests to revoke the patent in the UPC territories, and ordered Sanofi and Regeneron to bear the costs of both instances (EUR 1,375,000 each for first instance). The patent is maintained; the Court of Appeal found the claimed invention involved an inventive step.

    Show the legal issues (5)
    • Claim interpretation (medical use-format claims)
    • Added matter
    • Sufficiency of disclosure
    • Inventive step (PCSK9 antibodies)
    • Reasonable expectation of success
Documents
Document titleDatePublic
Decision2026-03-25Not public
Decision2026-03-25Public
Receipt2026-03-13Not public
Cover sheet2026-03-13Not public
Application Appellant2026-03-13Not public
Receipt2026-03-11Not public
Cover sheet2026-03-11Not public
Application Respondent2026-03-11Not public
Receipt2026-02-25Not public
Cover sheet2026-02-25Not public
Application Appellant2026-02-25Not public
Order2026-02-18Not public
Order2026-02-18Public
Receipt2026-02-05Not public
Cover sheet2026-02-05Not public
Application document Appellant2026-02-05Not public
Order2026-01-29Not public
Order2026-01-29Public
Receipt2026-01-26Not public
Cover sheet2026-01-26Not public
Other document Respondent2026-01-26Not public
Application document Respondent2026-01-26Not public
Exhibit document Respondent2026-01-26Not public
Exhibit document Respondent2026-01-26Not public
Exhibit document Respondent2026-01-26Not public
Exhibit document Respondent2026-01-26Not public
Exhibit document Respondent2026-01-26Not public
Case closed2025-11-25Not public
Decision2025-11-25Not public
Decision2025-11-25Public
Communication2025-11-24Not public
Oral procedure closed2025-09-22Not public
Oral procedure opened2025-09-22Not public
Written procedure closed2025-09-22Not public
Hearing Reference2025-08-13Not public
Hearing Reference2025-08-13Not public
Schedule for oral hearing2025-08-05Public
Receipt2025-06-26Not public
Receipt2025-06-26Not public
C1322025-06-25Not public
2025.06.25 EP797 UPC appeal - letter to CoA commenting on OD decision2025-06-25Not public
C1182025-06-25Not public
C1292025-06-25Not public
C1302025-06-25Not public
C1242025-06-25Not public
C1232025-06-25Not public
C1182025-06-25Not public
C1252025-06-25Not public
C1332025-06-25Not public
C1272025-06-25Not public
C1312025-06-25Not public
C1282025-06-25Not public
C1262025-06-25Not public
C1282025-06-25Not public
D102 - Decision Opposition Division of 21 May 2025 and minutes of the oral proceedings held on 31 March - 3 April 20252025-06-25Not public
Comments on the decision of the OD in opposition2025-06-25Not public
Outcome of the Order2025-05-26Not public
order on time extension2025-05-26Public
Receipt2025-05-22Not public
2025.05.22 - Request for extension deadline for providing comments on OD decision - signed2025-05-22Not public
Summons2025-05-06Public
Response to order dated 17 April2025-04-29Not public
Annex - Evidence of prior commitment2025-04-29Not public
Response to order dated 17 April2025-04-29Not public
Annex - Evidence of prior commitment2025-04-29Not public
Annex - Evidence of prior commitment2025-04-29Not public
Response to order dated 17 April2025-04-29Not public
Reply to CoA Order2025-04-29Not public
case management order2025-04-17Public
Template-Order2025-04-17Not public
Interim-Procedure-Closure2025-03-18Not public
Summon-Oral-Hearing2025-03-18Not public
order on IC2025-03-18Public
Interim-Conference-Decision2025-03-18Not public
Acknowledgement-of-lodging2025-02-17Not public
Acknowledgement-of-lodging2025-02-17Not public
Acknowledgement-of-lodging2025-02-17Not public
C115a2025-02-17Not public
C1202025-02-17Not public
C1152025-02-17Not public
C119a2025-02-17Not public
C1172025-02-17Not public
C1192025-02-17Not public
C118a2025-02-17Not public
C1162025-02-17Not public
C116a2025-02-17Not public
2025.02.17 Statement of Response - signed2025-02-17Not public
C121a2025-02-17Not public
C122a2025-02-17Not public
C120a2025-02-17Not public
C1212025-02-17Not public
C1182025-02-17Not public
C1222025-02-17Not public
C117a2025-02-17Not public
C1162025-02-17Not public
C119a2025-02-17Not public
C1212025-02-17Not public
C118a2025-02-17Not public
C121a2025-02-17Not public
C1202025-02-17Not public
C1172025-02-17Not public
C122a2025-02-17Not public
C120a2025-02-17Not public
C1222025-02-17Not public
C116a2025-02-17Not public
C1182025-02-17Not public
C117a2025-02-17Not public
C1192025-02-17Not public
C1152025-02-17Not public
C115a2025-02-17Not public
2025.02.17 Statement of Response - signed2025-02-17Not public
C116a2025-02-17Not public
C118a2025-02-17Not public
C122a2025-02-17Not public
C119a2025-02-17Not public
C1222025-02-17Not public
2025.02.17 Statement of Response - signed2025-02-17Not public
C115a2025-02-17Not public
C117a2025-02-17Not public
C1212025-02-17Not public
C1172025-02-17Not public
C1152025-02-17Not public
C1202025-02-17Not public
C121a2025-02-17Not public
C1182025-02-17Not public
C1192025-02-17Not public
C120a2025-02-17Not public
C1162025-02-17Not public
Summons to oral hearing2025-02-11Public
2025.02.05 - Submission on appeal hearing date (Sanofi _ RGN)2025-02-05Not public
2025.02.05 - Submission on appeal hearing date (Sanofi _ RGN)2025-02-05Not public
2025.02.05 - Submission on appeal hearing date (Sanofi _ RGN)2025-02-05Not public
Reply to Summons CoA2025-02-05Not public
Flight booking2025-02-05Not public
Summons2025-01-30Not public
Comments2025-01-27Not public
Comments2025-01-27Not public
Comments2025-01-27Not public
Request rescheduling hearing2025-01-24Not public
Summons TBA hearing2025-01-24Not public
Summons2025-01-22Not public
Panel-Appointment2024-12-11Not public
Acknowledgement-of-lodging2024-11-28Not public
Acknowledgement-of-lodging2024-11-15Not public
D1012024-11-15Not public
Annex 32024-11-15Not public
D1002024-11-15Not public
Statement of grounds of Appeal2024-11-15Not public
Acknowledgement-of-lodging2024-10-14Not public
2024.10.14 - Application to change details of a representative (signed)2024-10-14Not public
Panel-Appointment2024-10-07Not public
Receipt2024-10-07Not public
Acknowledgement-of-lodging2024-10-07Not public
Formal-checks_Notification-of-positive-outcome2024-10-07Not public
Proof of payment2024-10-02Not public
Statement of Appeal2024-10-02Not public
Rectified Statement of Appeal2024-10-02Not public
Formal-checks_Request-for-correction2024-10-02Not public
Rectified Statement of Appeal2024-10-02Not public
Proof of payment2024-10-02Not public
Formal-checks_Request-for-correction2024-09-24Not public
Acknowledgement-of-lodging2024-09-13Not public
Proof of payment2024-09-13Not public
Statement of Appeal2024-09-13Not public